OBJECTIVE: Vaginal deliveries have been associated with pelvic organ prolapse and incontinence. The objective was to show whether markers of ischemia/reperfusion injury are dependent upon the mode of delivery and length of labor. METHOD: Complete venipuncture sets were obtained on 62 subjects. All samples collected were analyzed for serum creatine phosphokinase (CPK) and lactate dehydrogenase (LDH). Lipid peroxidation was analyzed, using thiobarbituric acid reactive substances (TBARS), on a subset of 37 patients. RESULTS: There was a significant increase in CPK from admission to 1 h postpartum and postpartum day 1 in vaginal delivery versus cesarean delivery. Longer second stages were associated with significant increases in CPK. There were no significant changes in either LDH or TBARS from admission to any other time point regardless of mode of delivery. CONCLUSION: Vaginal delivery and longer second stages were associated with a much greater increase in one of these injury markers.
OBJECTIVE: Vaginal deliveries have been associated with pelvic organ prolapse and incontinence. The objective was to show whether markers of ischemia/reperfusion injury are dependent upon the mode of delivery and length of labor. METHOD: Complete venipuncture sets were obtained on 62 subjects. All samples collected were analyzed for serum creatine phosphokinase (CPK) and lactate dehydrogenase (LDH). Lipid peroxidation was analyzed, using thiobarbituric acid reactive substances (TBARS), on a subset of 37 patients. RESULTS: There was a significant increase in CPK from admission to 1 h postpartum and postpartum day 1 in vaginal delivery versus cesarean delivery. Longer second stages were associated with significant increases in CPK. There were no significant changes in either LDH or TBARS from admission to any other time point regardless of mode of delivery. CONCLUSION: Vaginal delivery and longer second stages were associated with a much greater increase in one of these injury markers.
Authors: Janis M Miller; Catherine Brandon; Jon A Jacobson; Lisa Kane Low; Ruth Zielinski; James Ashton-Miller; John O L Delancey Journal: AJR Am J Roentgenol Date: 2010-09 Impact factor: 3.959
Authors: María D Contreras-Aguilar; Pedro J Vallejo-Mateo; Elsa Lamy; Damián Escribano; Jose J Cerón; Fernando Tecles; Camila P Rubio Journal: Animals (Basel) Date: 2021-03-09 Impact factor: 2.752