Literature DB >> 1676746

Unusual solubility behaviour of cyclosporin A in aqueous media.

G Ismailos1, C Reppas, J B Dressman, P Macheras.   

Abstract

The solubility of cyclosporin A was determined in water and in Sorensen buffers at pH 1.2 and 6.6 at temperatures ranging from 5 to 37 degrees C. No differences in solubility behaviour were observed among the three aqueous media. Solubility was found to be inversely proportional to the temperature in each medium, indicating that the heat of solution was exothermic in each case.

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Year:  1991        PMID： 1676746     DOI： 10.1111/j.2042-7158.1991.tb06688.x

Source DB:  PubMed          Journal:  J Pharm Pharmacol        ISSN： 0022-3573            Impact factor:   3.765


  16 in total

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