BACKGROUND: Vagus nerve stimulation (VNS) and repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex are brain stimulation techniques used as therapeutic interventions in major depression. METHODS: In this study, we report the impact of these stimulation techniques on serum concentrations of brain-derived neurotrophic factor (BDNF) in treatment-resistant patients with a diagnosis of major depression. RESULTS: We found no changes of BDNF serum concentrations and no association of neurotrophin concentrations in serum with clinical parameters in our sample. CONCLUSION: Our preliminary results suggest that brain stimulation techniques-in contrast to several antidepressant medications-do not change BDNF serum concentrations.
BACKGROUND: Vagus nerve stimulation (VNS) and repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex are brain stimulation techniques used as therapeutic interventions in major depression. METHODS: In this study, we report the impact of these stimulation techniques on serum concentrations of brain-derived neurotrophic factor (BDNF) in treatment-resistant patients with a diagnosis of major depression. RESULTS: We found no changes of BDNF serum concentrations and no association of neurotrophin concentrations in serum with clinical parameters in our sample. CONCLUSION: Our preliminary results suggest that brain stimulation techniques-in contrast to several antidepressant medications-do not change BDNF serum concentrations.
Authors: Giovanni Assenza; Mario Tombini; Jacopo Lanzone; Lorenzo Ricci; Vincenzo Di Lazzaro; Sara Casciato; Alessandra Morano; Anna Teresa Giallonardo; Carlo Di Bonaventura; Ettore Beghi; Edoardo Ferlazzo; Sara Gasparini; Loretta Giuliano; Francesco Pisani; Paolo Benna; Francesca Bisulli; Fabrizio A De Falco; Silvana Franceschetti; Angela La Neve; Stefano Meletti; Barbara Mostacci; Ferdinando Sartucci; Pasquale Striano; Flavio Villani; Umberto Aguglia; Giuliano Avanzini; Vincenzo Belcastro; Amedeo Bianchi; Vittoria Cianci; Angelo Labate; Adriana Magaudda; Roberto Michelucci; Annapia Verri; Gaetano Zaccara; Vincenzo Pizza; Paolo Tinuper; Giancarlo Di Gennaro Journal: Neurol Sci Date: 2020-06-10 Impact factor: 3.307
Authors: Owen M Wolkowitz; Jessica Wolf; Wendy Shelly; Rebecca Rosser; Heather M Burke; George K Lerner; Victor I Reus; J Craig Nelson; Elissa S Epel; Synthia H Mellon Journal: Prog Neuropsychopharmacol Biol Psychiatry Date: 2011-07-03 Impact factor: 5.067
Authors: Robert I Henkin; Samuel J Potolicchio; Lucien M Levy; Ramy Moharram; Irina Velicu; Brian M Martin Journal: Am J Med Sci Date: 2010-03 Impact factor: 2.378
Authors: Natalie L Bulgin; John S Strauss; Nicole A King; Sajid A Shaikh; Charles J George; Nathan A Fox; Cathy L Barr; Maria Kovacs; James L Kennedy Journal: Neuromolecular Med Date: 2008-06-10 Impact factor: 3.843