Literature DB >> 16767383

Effect of transcorneal electrical stimulation in patients with nonarteritic ischemic optic neuropathy or traumatic optic neuropathy.

Takashi Fujikado1, Takeshi Morimoto, Kenji Matsushita, Hiroshi Shimojo, Yoshitaka Okawa, Yasuo Tano.   

Abstract

PURPOSE: To determine whether transcorneal electrical stimulation (TES) can improve the visual function of patients with nonarteritic ischemic optic neuropathy (NAION) or traumatic optic neuropathy (TON).
METHODS: Eight consecutive patients at the Osaka University Hospital were studied. TES (600-800 microA, 20 Hz, 30 min) was applied once each to three eyes with NAION and to five eyes with TON, using a contact lens-type stimulating electrode. The primary outcome measurement was the change in visual acuity at 1 to 3 months after TES. An improvement in visual acuity was defined as a change of > or =0.3 log (minimum angle of resolution) (logMAR) units. The side effects of TES were also investigated.
RESULTS: After TES application, the visual acuity improved in two patients with NAION and in four patients with TON. Visual acuity did not worsen in any of the eyes. Only a mild superficial punctuate keratopathy was observed in all eyes immediately after TES, and it healed by the next day.
CONCLUSIONS: Visual acuity can be improved after TES without major complications in some patients with NAION or TON. These results suggest that TES should be considered as a new treatment for eyes with optic neuropathy.

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Year:  2006        PMID: 16767383     DOI: 10.1007/s10384-005-0304-y

Source DB:  PubMed          Journal:  Jpn J Ophthalmol        ISSN: 0021-5155            Impact factor:   2.447


  16 in total

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Journal:  Neuroreport       Date:  2002-02-11       Impact factor: 1.837

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10.  Transcorneal electrical stimulation rescues axotomized retinal ganglion cells by activating endogenous retinal IGF-1 system.

Authors:  Takeshi Morimoto; Tomomitsu Miyoshi; Satoshi Matsuda; Yasuo Tano; Takashi Fujikado; Yutaka Fukuda
Journal:  Invest Ophthalmol Vis Sci       Date:  2005-06       Impact factor: 4.799

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  46 in total

1.  Electrical stimulation--a therapeutic strategy for retinal and optic nerve disease?

Authors:  Florian Gekeler; Karl Ulrich Bartz-Schmidt
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2012-01-27       Impact factor: 3.117

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Authors:  F Gekeler; E Zrenner; K U Bartz-Schmidt
Journal:  Ophthalmologe       Date:  2015-09       Impact factor: 1.059

3.  Effects of L-arginine on anatomical and electrophysiological deterioration of the eye in a rodent model of nonarteritic ischemic optic neuropathy.

Authors:  Hideki Chuman; Tomoyuki Maekubo; Takako Osako; Michitaka Ishiai; Naoko Kawano; Nobuhisa Nao-I
Journal:  Jpn J Ophthalmol       Date:  2013-05-29       Impact factor: 2.447

4.  Effects of steroid administration and transcorneal electrical stimulation on the anatomic and electrophysiologic deterioration of nonarteritic ischemic optic neuropathy in a rodent model.

Authors:  Takako Osako; Hideki Chuman; Tomoyuki Maekubo; Michitaka Ishiai; Naoko Kawano; Nobuhisa Nao-I
Journal:  Jpn J Ophthalmol       Date:  2013-05-09       Impact factor: 2.447

5.  [Effects of transcorneal electrical stimulation in patients with Stargardt's disease].

Authors:  T Röck; A Schatz; L Naycheva; M Gosheva; J Pach; B Wilhelm; T Peters; K U Bartz-Schmidt; E Zrenner; G Willmann; F Gekeler
Journal:  Ophthalmologe       Date:  2013-01       Impact factor: 1.059

Review 6.  Electrical stimulation of cranial nerves in cognition and disease.

Authors:  Devin Adair; Dennis Truong; Zeinab Esmaeilpour; Nigel Gebodh; Helen Borges; Libby Ho; J Douglas Bremner; Bashar W Badran; Vitaly Napadow; Vincent P Clark; Marom Bikson
Journal:  Brain Stimul       Date:  2020-02-23       Impact factor: 8.955

Review 7.  Treatment of nonarteritic anterior ischemic optic neuropathy.

Authors:  Edward J Atkins; Beau B Bruce; Nancy J Newman; Valérie Biousse
Journal:  Surv Ophthalmol       Date:  2010 Jan-Feb       Impact factor: 6.048

8.  Effect of electrical stimulation on IGF-1 transcription by L-type calcium channels in cultured retinal Müller cells.

Authors:  Tatsuhiko Sato; Takashi Fujikado; Takeshi Morimoto; Kenji Matsushita; Takayuki Harada; Yasuo Tano
Journal:  Jpn J Ophthalmol       Date:  2008-07-27       Impact factor: 2.447

9.  Transcorneal electrical stimulation improves visual function in eyes with branch retinal artery occlusion.

Authors:  Shinichirou Oono; Takuji Kurimoto; Ryosuke Kashimoto; Yuichi Tagami; Norio Okamoto; Osamu Mimura
Journal:  Clin Ophthalmol       Date:  2011-03-23

10.  Transcutaneous electrical retinal stimulation therapy for age-related macular degeneration.

Authors:  Kei Shinoda; Yutaka Imamura; Sayaka Matsuda; Maiko Seki; Atsuro Uchida; Terry Grossman; Kazuo Tsubota
Journal:  Open Ophthalmol J       Date:  2008-08-26
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