Literature DB >> 16763676

Analysis of the reactions used for the preparation of drug candidate molecules.

John S Carey1, David Laffan, Colin Thomson, Mike T Williams.   

Abstract

The purpose of this perspective is to indicate the range of chemistries used in the manufacture of drug candidate molecules and to highlight certain gaps in current technologies. To do this a survey was carried out of chemical syntheses within the Process Chemistry R&D departments of GlaxoSmithKline, AstraZeneca and Pfizer.

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Year:  2006        PMID: 16763676     DOI: 10.1039/b602413k

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN: 1477-0520            Impact factor:   3.876


  141 in total

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Authors:  Paul D Leeson; Stephen A St-Gallay
Journal:  Nat Rev Drug Discov       Date:  2011-09-30       Impact factor: 84.694

2.  Reaction of lithium diethylamide with an alkyl bromide and alkyl benzenesulfonate: origins of alkylation, elimination, and sulfonation.

Authors:  Lekha Gupta; Antonio Ramírez; David B Collum
Journal:  J Org Chem       Date:  2010-11-16       Impact factor: 4.354

3.  Rh(I)-catalyzed direct arylation of azines.

Authors:  Ashley M Berman; Robert G Bergman; Jonathan A Ellman
Journal:  J Org Chem       Date:  2010-10-29       Impact factor: 4.354

4.  Synthesis of dihydropyridines and pyridines from imines and alkynes via C-H activation.

Authors:  Denise A Colby; Robert G Bergman; Jonathan A Ellman
Journal:  J Am Chem Soc       Date:  2008-02-27       Impact factor: 15.419

5.  Synthesis of isoquinuclidines from highly substituted dihydropyridines via the Diels-Alder reaction.

Authors:  Rhia M Martin; Robert G Bergman; Jonathan A Ellman
Journal:  Org Lett       Date:  2013-01-15       Impact factor: 6.005

6.  Redox cycloisomerization approach to 1,2-dihydropyridines.

Authors:  Barry M Trost; Berenger Biannic
Journal:  Org Lett       Date:  2015-03-11       Impact factor: 6.005

7.  Pd(II)-catalyzed olefination of electron-deficient arenes using 2,6-dialkylpyridine ligands.

Authors:  Yang-Hui Zhang; Bing-Feng Shi; Jin-Quan Yu
Journal:  J Am Chem Soc       Date:  2009-04-15       Impact factor: 15.419

Review 8.  Biaryl phosphane ligands in palladium-catalyzed amination.

Authors:  David S Surry; Stephen L Buchwald
Journal:  Angew Chem Int Ed Engl       Date:  2008       Impact factor: 15.336

9.  Rh(I)-catalyzed direct arylation of pyridines and quinolines.

Authors:  Ashley M Berman; Jared C Lewis; Robert G Bergman; Jonathan A Ellman
Journal:  J Am Chem Soc       Date:  2008-10-15       Impact factor: 15.419

10.  Rh(III)-catalyzed regioselective synthesis of pyridines from alkenes and α,β-unsaturated oxime esters.

Authors:  Jamie M Neely; Tomislav Rovis
Journal:  J Am Chem Soc       Date:  2012-12-18       Impact factor: 15.419

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