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Literature DB >> 16762328

Multi-enzyme one-pot strategy for the synthesis of sialyl Lewis X-containing PSGL-1 glycopeptide.

Kuo-Ting Huang¹, Bing-Ching Wu, Chang-Ching Lin, Shih-Chi Luo, Chinpan Chen, Chi-Huey Wong, Chun-Cheng Lin.

Abstract

An enzymatic one-pot three-step glycosylation strategy was developed for the synthesis of sLex moiety of truncated PSGL-1 glycopeptide with and without sulfation. The method provided an efficient way to afford complex glycopeptides in a semi-preparative scale without further complicated and time-consuming purification process in each glycosylation step.

Entities: Chemical Gene

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Year: 2006 PMID： 16762328 DOI： 10.1016/j.carres.2006.04.047

Source DB: PubMed Journal: Carbohydr Res ISSN： 0008-6215 Impact factor: 2.104

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Cited

10 in total

1. Cloning and characterization of a viral α2-3-sialyltransferase (vST3Gal-I) for the synthesis of sialyl Lewisx.

Authors: Go Sugiarto; Kam Lau; Hai Yu; Stephanie Vuong; Vireak Thon; Yanhong Li; Shengshu Huang; Xi Chen
Journal: Glycobiology Date: 2010-10-26 Impact factor: 4.313

2. Synthesis of an Fmoc-threonine bearing core-2 glycan: a building block for PSGL-1 via Fmoc-assisted solid-phase peptide synthesis.

Authors: Venkata R Krishnamurthy; Ann Dougherty; Medha Kamat; Xuezheng Song; Richard D Cummings; Elliot L Chaikof
Journal: Carbohydr Res Date: 2010-05-12 Impact factor: 2.104

Review 3. Targeting P-selectin glycoprotein ligand-1/P-selectin interactions as a novel therapy for metabolic syndrome.

Authors: Madhukar S Patel; David Miranda-Nieves; Jiaxuan Chen; Carolyn A Haller; Elliot L Chaikof
Journal: Transl Res Date: 2016-12-09 Impact factor: 7.012

4. Rapid assembly of oligosaccharides: a highly convergent strategy for the assembly of a glycosylated amino acid derived from PSGL-1.

Authors: Yusuf Vohra; Therese Buskas; Geert-Jan Boons
Journal: J Org Chem Date: 2009-08-21 Impact factor: 4.354

5. Pathway engineered enzymatic de novo purine nucleotide synthesis.

Authors: Heather L Schultheisz; Blair R Szymczyna; Lincoln G Scott; James R Williamson
Journal: ACS Chem Biol Date: 2008-08-15 Impact factor: 5.100

6. Glycopeptide analogues of PSGL-1 inhibit P-selectin in vitro and in vivo.

Authors: Venkata R Krishnamurthy; Mohammed Y R Sardar; Yu Ying; Xuezheng Song; Carolyn Haller; Erbin Dai; Xiaocong Wang; Donny Hanjaya-Putra; Lijun Sun; Vasilios Morikis; Scott I Simon; Robert J Woods; Richard D Cummings; Elliot L Chaikof
Journal: Nat Commun Date: 2015-03-31 Impact factor: 14.919

Multi-enzyme one-pot strategy for the synthesis of sialyl Lewis X-containing PSGL-1 glycopeptide.

1. Cloning and characterization of a viral α2-3-sialyltransferase (vST3Gal-I) for the synthesis of sialyl Lewisx.

2. Synthesis of an Fmoc-threonine bearing core-2 glycan: a building block for PSGL-1 via Fmoc-assisted solid-phase peptide synthesis.

Review 3. Targeting P-selectin glycoprotein ligand-1/P-selectin interactions as a novel therapy for metabolic syndrome.

4. Rapid assembly of oligosaccharides: a highly convergent strategy for the assembly of a glycosylated amino acid derived from PSGL-1.

5. Pathway engineered enzymatic de novo purine nucleotide synthesis.

6. Glycopeptide analogues of PSGL-1 inhibit P-selectin in vitro and in vivo.

7. An enzymatic platform for the synthesis of isoprenoid precursors.

Review 8. The Tn antigen-structural simplicity and biological complexity.

9. Me₃SI-promoted chemoselective deacetylation: a general and mild protocol.

Review 10. An in vitro synthetic biology platform for emerging industrial biomanufacturing: Bottom-up pathway design.