Literature DB >> 16759713

Assembling a smallpox biodefense by interrogating 5-substituted pyrimidine nucleoside chemical space.

Xuesen Fan1, Xinying Zhang, Longhu Zhou, Kathy A Keith, Earl R Kern, Paul F Torrence.   

Abstract

The nucleoside 5-formyl-2'-deoxyuridine has been used as a starting point for the generation of novel 5-substituted pyrimidine nucleosides that are shown to possess significant antiviral activity against two representative orthopoxviruses, namely vaccinia virus and cowpox virus.

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Year:  2006        PMID： 16759713     DOI： 10.1016/j.antiviral.2006.04.015

Source DB:  PubMed          Journal:  Antiviral Res        ISSN： 0166-3542            Impact factor:   5.970


  7 in total

1.  Synthesis and antiviral activities of new acyclic and "double-headed" nucleoside analogues.

Authors:  Xinying Zhang; Adel Amer; Xuesen Fan; Jan Balzarini; Johan Neyts; Erik De Clercq; Mark Prichard; Earl Kern; Paul F Torrence
Journal:  Bioorg Chem       Date:  2006-12-02       Impact factor: 5.275

2.  Selective phosphorylation of antiviral drugs by vaccinia virus thymidine kinase.

Authors:  Mark N Prichard; Kathy A Keith; Mary P Johnson; Emma A Harden; Alexis McBrayer; Ming Luo; Shihong Qiu; Debasish Chattopadhyay; Xuesen Fan; Paul F Torrence; Earl R Kern
Journal:  Antimicrob Agents Chemother       Date:  2007-02-26       Impact factor: 5.191

3.  Ionic liquid promoted preparation of 4H-thiopyran and pyrimidine nucleoside-thiopyran hybrids through one-pot multi-component reaction of thioamide.

Authors:  Xinying Zhang; Xiaoyan Li; Xuesen Fan; Xia Wang; Dongfang Li; Guirong Qu; Jianji Wang
Journal:  Mol Divers       Date:  2008-12-09       Impact factor: 2.943

4.  Antiviral Activity of 4'-thioIDU and Thymidine Analogs against Orthopoxviruses.

Authors:  Mark N Prichard; Earl R Kern
Journal:  Viruses       Date:  2010-09-16       Impact factor: 5.818

5.  [(2R,3S,5R)-3-Acet-oxy-5-(5-formyl-2,4-dioxo-1,2,3,4-tetra-hydro-pyrimidin-1-yl)-2,3,4,5-tetra-hydro-furan-2-yl]methyl acetate.

Authors:  Xue-Fei Jia; Nan Liu; Liang-Liang Fang; Xin-Ying Zhang
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-10-12

6.  Ionic liquid-promoted multi-component reaction: novel and efficient preparation of pyrazolo[3,4-b]pyridinone, pyrazolo[3,4-b]-quinolinone and their hybrids with pyrimidine nucleoside.

Authors:  Xinying Zhang; Dongfang Li; Xuesen Fan; Xia Wang; Xiaoyan Li; Guirong Qu; Jianji Wang
Journal:  Mol Divers       Date:  2009-06-12       Impact factor: 3.364

Review 7.  Multicomponent reactions in nucleoside chemistry.

Authors:  Mariola Koszytkowska-Stawińska; Włodzimierz Buchowicz
Journal:  Beilstein J Org Chem       Date:  2014-07-29       Impact factor: 2.883
  7 in total

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