Literature DB >> 16759083

Multivalent antimicrobial peptides from a reactive polymer scaffold.

Zhigang Liu1, Heather Deshazer, Amanda J Rice, Kang Chen, Chunhui Zhou, Neville R Kallenbach.   

Abstract

We report an application of the principle of multivalency to create new antimicrobial agents using the reactive polymaleic anhydride (PMA) chain to link antimicrobial tetrapeptides to afford multivalent variants containing approximately 40 monomer units. Relative to the free peptides, the product shows a 10-fold improvement in IC(50) without provoking more severe hemolysis of red blood cells. Thus, multivalency or polyvalency may offer a route to enhance the activity of antimicrobial peptides.

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Year:  2006        PMID： 16759083     DOI： 10.1021/jm0601452

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  14 in total

1.  Effects of dimerization on the structure and biological activity of antimicrobial peptide Ctx-Ha.

Authors:  E N Lorenzón; G F Cespedes; E F Vicente; L G Nogueira; T M Bauab; M S Castro; E M Cilli
Journal:  Antimicrob Agents Chemother       Date:  2012-03-05       Impact factor: 5.191

2.  Rationale-based, de novo design of dehydrophenylalanine-containing antibiotic peptides and systematic modification in sequence for enhanced potency.

Authors:  Sarika Pathak; Virander Singh Chauhan
Journal:  Antimicrob Agents Chemother       Date:  2011-02-14       Impact factor: 5.191

3.  Length effects in antimicrobial peptides of the (RW)n series.

Authors:  Zhigang Liu; Anna Brady; Anne Young; Brian Rasimick; Kang Chen; Chunhui Zhou; Neville R Kallenbach
Journal:  Antimicrob Agents Chemother       Date:  2006-12-04       Impact factor: 5.191

4.  Progressive structuring of a branched antimicrobial peptide on the path to the inner membrane target.

Authors:  Yang Bai; Shouping Liu; Jianguo Li; Rajamani Lakshminarayanan; Padmanabhan Sarawathi; Charles Tang; Duncun Ho; Chandra Verma; Roger W Beuerman; Konstantin Pervushin
Journal:  J Biol Chem       Date:  2012-06-14       Impact factor: 5.157

5.  Macrocyclic chelator assembled RGD multimers for tumor targeting.

Authors:  Xiaofen Zhang; Hongguang Liu; Zheng Miao; Richard Kimura; Feiyue Fan; Zhen Cheng
Journal:  Bioorg Med Chem Lett       Date:  2011-04-05       Impact factor: 2.823

6.  Multivalent benzoboroxole functionalized polymers as gp120 glycan targeted microbicide entry inhibitors.

Authors:  Julie I Jay; Bonnie E Lai; David G Myszka; Alamelu Mahalingam; Kris Langheinrich; David F Katz; Patrick F Kiser
Journal:  Mol Pharm       Date:  2010-02-01       Impact factor: 4.939

7.  Multivalent Antimicrobial Peptides as Therapeutics: Design Principles and Structural Diversities.

Authors:  S P Liu; L Zhou; R Lakshminarayanan; R W Beuerman
Journal:  Int J Pept Res Ther       Date:  2010-08-26       Impact factor: 1.931

8.  Effects of Trp- and Arg-containing antimicrobial-peptide structure on inhibition of Escherichia coli planktonic growth and biofilm formation.

Authors:  Shuyu Hou; Zhigang Liu; Anne W Young; Sheron L Mark; Neville R Kallenbach; Dacheng Ren
Journal:  Appl Environ Microbiol       Date:  2010-01-22       Impact factor: 4.792

9.  Antimicrobial polymers prepared by ROMP with unprecedented selectivity: a molecular construction kit approach.

Authors:  Karen Lienkamp; Ahmad E Madkour; Ashlan Musante; Christopher F Nelson; Klaus Nüsslein; Gregory N Tew
Journal:  J Am Chem Soc       Date:  2008-07-01       Impact factor: 15.419

10.  Enhanced chiral recognition by cyclodextrin dimers.

Authors:  Jens Voskuhl; Kira Schaepe; Bart Jan Ravoo
Journal:  Int J Mol Sci       Date:  2011-07-18       Impact factor: 5.923
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