Literature DB >> 21524578

Macrocyclic chelator assembled RGD multimers for tumor targeting.

Xiaofen Zhang1, Hongguang Liu, Zheng Miao, Richard Kimura, Feiyue Fan, Zhen Cheng.   

Abstract

Macrocyclic chelators have been extensively used for complexation of metal ions. A widely used chelator, DOTA, has been explored as a molecular platform to assemble multiple bioactive peptides in this paper. The multivalent DOTA-peptide bioconjugates demonstrate promising tumor targeting ability.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID: 21524578      PMCID: PMC3098922          DOI: 10.1016/j.bmcl.2011.03.110

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  32 in total

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Authors:  Shuang Liu
Journal:  Chem Soc Rev       Date:  2004-08-16       Impact factor: 54.564

2.  Imaging chemically modified adenovirus for targeting tumors expressing integrin alphavbeta3 in living mice with mutant herpes simplex virus type 1 thymidine kinase PET reporter gene.

Authors:  Zhengming Xiong; Zhen Cheng; Xianzhong Zhang; Manish Patel; Joseph C Wu; Sanjiv S Gambhir; Xiaoyuan Chen
Journal:  J Nucl Med       Date:  2006-01       Impact factor: 10.057

3.  Multivalent antimicrobial peptides from a reactive polymer scaffold.

Authors:  Zhigang Liu; Heather Deshazer; Amanda J Rice; Kang Chen; Chunhui Zhou; Neville R Kallenbach
Journal:  J Med Chem       Date:  2006-06-15       Impact factor: 7.446

Review 4.  Bifunctional coupling agents for radiolabeling of biomolecules and target-specific delivery of metallic radionuclides.

Authors:  Shuang Liu
Journal:  Adv Drug Deliv Rev       Date:  2008-04-23       Impact factor: 15.470

5.  microPET imaging of glioma integrin {alpha}v{beta}3 expression using (64)Cu-labeled tetrameric RGD peptide.

Authors:  Yun Wu; Xianzhong Zhang; Zhengming Xiong; Zhen Cheng; Darrell R Fisher; Shuang Liu; Sanjiv S Gambhir; Xiaoyuan Chen
Journal:  J Nucl Med       Date:  2005-10       Impact factor: 10.057

6.  Radiolabeled affibody-albumin bioconjugates for HER2-positive cancer targeting.

Authors:  Susan Hoppmann; Zheng Miao; Shuanglong Liu; Hongguang Liu; Gang Ren; Ande Bao; Zhen Cheng
Journal:  Bioconjug Chem       Date:  2011-02-07       Impact factor: 4.774

Review 7.  Radiolabeled multimeric cyclic RGD peptides as integrin alphavbeta3 targeted radiotracers for tumor imaging.

Authors:  Shuang Liu
Journal:  Mol Pharm       Date:  2006 Sep-Oct       Impact factor: 4.939

8.  Evaluation of a (64)Cu-labeled cystine-knot peptide based on agouti-related protein for PET of tumors expressing alphavbeta3 integrin.

Authors:  Lei Jiang; Richard H Kimura; Zheng Miao; Adam P Silverman; Gang Ren; Hongguang Liu; Peiyong Li; Sanjiv Sam Gambhir; Jennifer R Cochran; Zhen Cheng
Journal:  J Nucl Med       Date:  2010-02       Impact factor: 10.057

9.  (64)Cu-labeled tetrameric and octameric RGD peptides for small-animal PET of tumor alpha(v)beta(3) integrin expression.

Authors:  Zi-Bo Li; Weibo Cai; Qizhen Cao; Kai Chen; Zhanhong Wu; Lina He; Xiaoyuan Chen
Journal:  J Nucl Med       Date:  2007-06-15       Impact factor: 10.057

10.  Polyvalent carbocyanine molecular beacons for molecular recognitions.

Authors:  Yunpeng Ye; Sharon Bloch; Samuel Achilefu
Journal:  J Am Chem Soc       Date:  2004-06-30       Impact factor: 15.419

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  3 in total

1.  Multivalent bifunctional chelator scaffolds for gallium-68 based positron emission tomography imaging probe design: signal amplification via multivalency.

Authors:  Ajay N Singh; Wei Liu; Guiyang Hao; Amit Kumar; Anjali Gupta; Orhan K Öz; Jer-Tsong Hsieh; Xiankai Sun
Journal:  Bioconjug Chem       Date:  2011-07-26       Impact factor: 4.774

2.  The efficient synthesis and biological evaluation of novel bi-functionalized sarcophagine for (64)cu radiopharmaceuticals.

Authors:  Shuanglong Liu; Dan Li; Chiun-Wei Huang; Li-Peng Yap; Ryan Park; Hong Shan; Zibo Li; Peter S Conti
Journal:  Theranostics       Date:  2012-06-12       Impact factor: 11.556

Review 3.  Chelators for copper radionuclides in positron emission tomography radiopharmaceuticals.

Authors:  Zhengxin Cai; Carolyn J Anderson
Journal:  J Labelled Comp Radiopharm       Date:  2013-12-18       Impact factor: 1.921

  3 in total

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