| Literature DB >> 16756302 |
Masato Iwatsuki1, Hiroshi Tomoda, Ryuji Uchida, Hiroaki Gouda, Shuichi Hirono, Satoshi Omura.
Abstract
Two antimycobacterial agents, lariatins A and B, were isolated from the culture broth of Rhodococcus sp. K01-B0171. Their structures were elucidated by spectral analysis and advanced protein chemical methods to be unique cyclic peptides, which consist of 18 and 20 L-amino acid residues with an internal linkage between the gamma-carboxyl group of Glu8 and the alpha-amino group of Gly1. The three-dimensional structure of lariatin A deduced from NMR data by dynamical simulated annealing method indicates that the tail segment (Trp9-Pro18) passes through the ring segment (Gly1-Glu8) to form a 'lasso' structure.Entities:
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Year: 2006 PMID： 16756302 DOI： 10.1021/ja056780z
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419