Literature DB >> 16753573

Hap1 and GABA: thinking about food intake.

Stephen C Woods1, Randy J Seeley.   

Abstract

GABA stimulation of hypothalamic GABAA receptors increases food intake and body weight. Huntingtin-associated protein-1 (Hap1), is highly expressed in the hypothalamus and increases activity at GABAA receptors; mice lacking Hap1 are hypophagic. A recent paper (Sheng et al.,2006) further explores the role of Hap1 in the control of food intake.

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Year:  2006        PMID: 16753573     DOI: 10.1016/j.cmet.2006.05.007

Source DB:  PubMed          Journal:  Cell Metab        ISSN: 1550-4131            Impact factor:   27.287


  6 in total

1.  HAP1 helps to regulate actin-based transport of insulin-containing granules in pancreatic β cells.

Authors:  Zhiyong Wang; Ting Peng; Hongnian Wu; Jun He; He Li
Journal:  Histochem Cell Biol       Date:  2015-03-06       Impact factor: 4.304

Review 2.  Huntingtin associated protein 1 and its functions.

Authors:  Linda Lin-yan Wu; Xin-Fu Zhou
Journal:  Cell Adh Migr       Date:  2009-01-26       Impact factor: 3.405

3.  Convergence between biological, behavioural and genetic determinants of obesity.

Authors:  Sujoy Ghosh; Claude Bouchard
Journal:  Nat Rev Genet       Date:  2017-10-09       Impact factor: 53.242

4.  HAP1 Modulates Epileptic Seizures by Regulating GABAAR Function in Patients with Temporal Lobe Epilepsy and in the PTZ-Induced Epileptic Model.

Authors:  Rong Li; Bing Wu; Miaoqing He; Peng Zhang; Qinbin Zhang; Jing Deng; Jinxian Yuan; Yangmei Chen
Journal:  Neurochem Res       Date:  2020-05-17       Impact factor: 3.996

5.  MAP2K3 is associated with body mass index in American Indians and Caucasians and may mediate hypothalamic inflammation.

Authors:  Li Bian; Michael Traurig; Robert L Hanson; Alejandra Marinelarena; Sayuko Kobes; Yunhua L Muller; Alka Malhotra; Ke Huang; Jessica Perez; Alex Gale; William C Knowler; Clifton Bogardus; Leslie J Baier
Journal:  Hum Mol Genet       Date:  2013-07-03       Impact factor: 6.150

6.  Inhibition of deprivation-induced food intake by GABA(A) antagonists: roles of the hypothalamic, endocrine and alimentary mechanisms.

Authors:  Ganesan L Kamatchi; Palaniswami Rathanaswami
Journal:  J Clin Biochem Nutr       Date:  2012-06-08       Impact factor: 3.114

  6 in total

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