BACKGROUND AND OBJECTIVE: To correlate structure and function in eyes with end-stage glaucoma. PATIENTS AND METHODS: Fifty-six eyes of 48 patients with glaucoma presenting with end-stage glaucoma underwent scanning laser polarimetry (SLP) imaging using a commercially available GDx-variable corneal compensator unit (GDx-VCC; Laser Diagnostics Technologies, Inc., San Diego, CA). End-stage glaucoma was defined by both disc appearance and standard automated perimetry visual field criteria. Standard automated perimetry parameters included: mean deviation, pattern standard deviation, and total deviation plot. GDx parameters included: TSNIT average, superior average, inferior average, TSNIT standard deviation, and nerve fiber indicator. RESULTS: The visual field mean deviation was -26.75 +/- 3.50 dB. The remaining retinal nerve fiber layer measured in this group of eyes was: TSNIT average, 29.76 +/- 5.81 microm; superior average, 30.76 +/- 6.25 microm; and inferior average, 31.14 +/- 7.20 microm. A low structure-function correlation was found when analyzing separately the superior and inferior hemifields (R2 = 0.00001, R2 = 0.0016, respectively). CONCLUSIONS: In eyes with end-stage glaucoma, very thin but existing retinal nerve fiber layer is found on SLP. Such values rarely dropped below 10 to 20 microm. A flattening of the GDx TSNIT pattern was seen, and the correlation between structure and function was not evident.
BACKGROUND AND OBJECTIVE: To correlate structure and function in eyes with end-stage glaucoma. PATIENTS AND METHODS: Fifty-six eyes of 48 patients with glaucoma presenting with end-stage glaucoma underwent scanning laser polarimetry (SLP) imaging using a commercially available GDx-variable corneal compensator unit (GDx-VCC; Laser Diagnostics Technologies, Inc., San Diego, CA). End-stage glaucoma was defined by both disc appearance and standard automated perimetry visual field criteria. Standard automated perimetry parameters included: mean deviation, pattern standard deviation, and total deviation plot. GDx parameters included: TSNIT average, superior average, inferior average, TSNIT standard deviation, and nerve fiber indicator. RESULTS: The visual field mean deviation was -26.75 +/- 3.50 dB. The remaining retinal nerve fiber layer measured in this group of eyes was: TSNIT average, 29.76 +/- 5.81 microm; superior average, 30.76 +/- 6.25 microm; and inferior average, 31.14 +/- 7.20 microm. A low structure-function correlation was found when analyzing separately the superior and inferior hemifields (R2 = 0.00001, R2 = 0.0016, respectively). CONCLUSIONS: In eyes with end-stage glaucoma, very thin but existing retinal nerve fiber layer is found on SLP. Such values rarely dropped below 10 to 20 microm. A flattening of the GDx TSNIT pattern was seen, and the correlation between structure and function was not evident.
Authors: Jean-Claude Mwanza; Hanna Y Kim; Donald L Budenz; Joshua L Warren; Michael Margolis; Scott D Lawrence; Pooja D Jani; Garrett S Thompson; Richard K Lee Journal: Invest Ophthalmol Vis Sci Date: 2015-10 Impact factor: 4.799
Authors: T S Vajaranant; R J Anderson; R Zelkha; C Zhang; J T Wilensky; D P Edward; M Shahidi Journal: Eye (Lond) Date: 2011-02-25 Impact factor: 3.775
Authors: Julio E DeLeón Ortega; Lisandro M Sakata; Bobby Kakati; Gerald McGwin; Blythe E Monheit; Stella N Arthur; Christopher A Girkin Journal: Invest Ophthalmol Vis Sci Date: 2007-03 Impact factor: 4.799
Authors: Jean-Claude Mwanza; Donald L Budenz; Joshua L Warren; Aaron D Webel; Courtney E Reynolds; Diego T Barbosa; Shan Lin Journal: Br J Ophthalmol Date: 2014-12-09 Impact factor: 4.638
Authors: Felipe A Medeiros; Luciana M Alencar; Linda M Zangwill; Pamela A Sample; Robert N Weinreb Journal: Ophthalmology Date: 2009-04-19 Impact factor: 12.079