PURPOSE: To determine whether there were differences in the structure-function relationship between early and advanced glaucoma, and study the association between thickness of discrete macular cell layers, the thickness of the retinal nerve fiber layer, and visual field sensitivity. METHODS: In all, 71 eyes of 50 subjects (28 glaucoma patients and 22 normal control subjects) were included. Thickness of macular retinal nerve fiber layer (mRNFL), macular inner retinal layer (mIRL), and macular outer retinal layer (mORL) were measured from Stratus optical coherence tomography macular scans, using our previously published segmentation algorithm. Visual sensitivity loss was determined by mean deviation (MD) using Humphrey Visual Field Analyzer. The mean thickness for each layer from the normal control subjects, early, and advanced glaucoma groups was compared. In addition, a mixed model analysis was used to explore the relationship between structure-function, allowing for possible interaction with glaucoma stage. RESULTS: The mean mRNFL thickness in early and advanced glaucoma patients was significantly less than measurements in normal subjects (P<0.01). The mean mIRL thickness in advanced glaucoma was significantly less than normal subjects (P=0.04). The mean mORL thickness in early and advanced glaucoma was not statistically significant different from that of normal subjects (P>0.8). There was no statistically significant difference in macular structure-function relationship between the two glaucoma groups (P>0.05). Mean mIRL thickness was significantly associated with MD (P=0.04). CONCLUSION: There was no significant difference in macular structure-function relationship between early and advanced glaucoma groups. Combined data from both glaucoma groups indicated that mIRL thickness was associated with visual sensitivity loss.
PURPOSE: To determine whether there were differences in the structure-function relationship between early and advanced glaucoma, and study the association between thickness of discrete macular cell layers, the thickness of the retinal nerve fiber layer, and visual field sensitivity. METHODS: In all, 71 eyes of 50 subjects (28 glaucomapatients and 22 normal control subjects) were included. Thickness of macular retinal nerve fiber layer (mRNFL), macular inner retinal layer (mIRL), and macular outer retinal layer (mORL) were measured from Stratus optical coherence tomography macular scans, using our previously published segmentation algorithm. Visual sensitivity loss was determined by mean deviation (MD) using Humphrey Visual Field Analyzer. The mean thickness for each layer from the normal control subjects, early, and advanced glaucoma groups was compared. In addition, a mixed model analysis was used to explore the relationship between structure-function, allowing for possible interaction with glaucoma stage. RESULTS: The mean mRNFL thickness in early and advanced glaucomapatients was significantly less than measurements in normal subjects (P<0.01). The mean mIRL thickness in advanced glaucoma was significantly less than normal subjects (P=0.04). The mean mORL thickness in early and advanced glaucoma was not statistically significant different from that of normal subjects (P>0.8). There was no statistically significant difference in macular structure-function relationship between the two glaucoma groups (P>0.05). Mean mIRL thickness was significantly associated with MD (P=0.04). CONCLUSION: There was no significant difference in macular structure-function relationship between early and advanced glaucoma groups. Combined data from both glaucoma groups indicated that mIRL thickness was associated with visual sensitivity loss.
Authors: Christopher A Girkin; Pamela A Sample; Jeffrey M Liebmann; Sonia Jain; Christopher Bowd; Lida M Becerra; Felipe A Medeiros; Lyne Racette; Keri A Dirkes; Robert N Weinreb; Linda M Zangwill Journal: Arch Ophthalmol Date: 2010-05
Authors: Hiroshi Ishikawa; Daniel M Stein; Gadi Wollstein; Siobahn Beaton; James G Fujimoto; Joel S Schuman Journal: Invest Ophthalmol Vis Sci Date: 2005-06 Impact factor: 4.799
Authors: Christopher K S Leung; Wai-Man Chan; Wing-Ho Yung; Alan C K Ng; Jackson Woo; Moon-Kong Tsang; Raymond K K Tse Journal: Ophthalmology Date: 2005-03 Impact factor: 12.079
Authors: Viviane Guedes; Joel S Schuman; Ellen Hertzmark; Gadi Wollstein; Anthony Correnti; Ronald Mancini; David Lederer; Serineh Voskanian; Leonardo Velazquez; Helena M Pakter; Tamar Pedut-Kloizman; James G Fujimoto; Cynthia Mattox Journal: Ophthalmology Date: 2003-01 Impact factor: 12.079
Authors: Kouros Nouri-Mahdavi; Douglas Hoffman; Dana P Tannenbaum; Simon K Law; Joseph Caprioli Journal: Am J Ophthalmol Date: 2004-02 Impact factor: 5.258
Authors: Pilar Cifuentes-Canorea; Jorge Ruiz-Medrano; Rosa Gutierrez-Bonet; Pablo Peña-Garcia; Federico Saenz-Frances; Julian Garcia-Feijoo; Jose Maria Martinez-de-la-Casa Journal: PLoS One Date: 2018-04-19 Impact factor: 3.240
Authors: Mark Christopher; Akram Belghith; Robert N Weinreb; Christopher Bowd; Michael H Goldbaum; Luke J Saunders; Felipe A Medeiros; Linda M Zangwill Journal: Invest Ophthalmol Vis Sci Date: 2018-06-01 Impact factor: 4.799