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Literature DB >> 1674913

Detection of multidrug-resistant protein, P-glycoprotein in childhood leukaemia and lymphoma.

Y Mizuno¹, T Hara, M Nagata, A Tawa, T Tsuruo, K Ueda.

Abstract

Flow cytometric detection of surface P-glycoprotein, a multidrug-resistant gene product, with a monoclonal antibody, MRK 16, was performed on cells obtained from 18 children with leukaemia and lymphoma. Of 18 patients examined, 1 with malignant lymphoma at relapse showed a significant increase in P-glycoprotein-positive cells and a strong resistance to chemotherapy. Overexpression of P-glycoprotein in a case with B-cell type malignant lymphoma was confirmed by immuno-precipitation and Northern hybridization analysis. The present study suggests that an increased expression of surface P-glycoprotein might be involved in multidrug resistance at least in a certain case of childhood leukaemia and lymphoma.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1991 PMID： 1674913 DOI： 10.1007/bf02093722

Source DB: PubMed Journal: Eur J Pediatr ISSN： 0340-6199 Impact factor: 3.183

11 in total

1. Immunocytochemical detection of a resistance-associated glycoprotein in tissue culture cells, ascites tumors and human tumor xenografts by Mab 265/F4.

Authors: M Volm; M Bak; T Efferth; B Lathan; J Mattern
Journal: Anticancer Res Date: 1988 Jul-Aug Impact factor: 2.480

2. Failure to detect the P-glycoprotein multidrug resistant phenotype in cases of resistant childhood acute lymphocytic leukaemia.

Authors: P Ubezio; M Limonta; M D'Incalci; G Damia; G Masera; G Giudici; J S Wolverton; W T Beck
Journal: Eur J Cancer Clin Oncol Date: 1989-12

Review 3. Multiple-drug resistance in human cancer.

Authors: I Pastan; M Gottesman
Journal: N Engl J Med Date: 1987-05-28 Impact factor: 91.245

4. P-glycoprotein in acute nonlymphoblastic leukemia and in the blastic crisis of myeloid leukemia.

Authors: G Carulli; M Petrini; A Marini; F Ambrogi
Journal: N Engl J Med Date: 1988-09-22 Impact factor: 91.245

5. Increased P-glycoprotein expression and multidrug-resistant gene (mdr1) amplification are infrequently found in fresh acute leukemia cells. Sequential analysis of 15 cases at initial presentation and relapsed stage.

Authors: Y Ito; M Tanimoto; T Kumazawa; M Okumura; Y Morishima; R Ohno; H Saito
Journal: Cancer Date: 1989-04-15 Impact factor: 6.860

6. Detection of P-glycoprotein in human leukemias using monoclonal antibodies.

Authors: J Mattern; T Efferth; M Bak; A D Ho; M Volm
Journal: Blut Date: 1989-04

7. Classification of chronic granulomatous disease on the basis of monoclonal antibody-defined surface cytochrome b deficiency.

Authors: Y Mizuno; T Hara; M Nakamura; K Ueda; S Minakami; H Take
Journal: J Pediatr Date: 1988-09 Impact factor: 4.406

Detection of multidrug-resistant protein, P-glycoprotein in childhood leukaemia and lymphoma.

1. Immunocytochemical detection of a resistance-associated glycoprotein in tissue culture cells, ascites tumors and human tumor xenografts by Mab 265/F4.

2. Failure to detect the P-glycoprotein multidrug resistant phenotype in cases of resistant childhood acute lymphocytic leukaemia.

Review 3. Multiple-drug resistance in human cancer.

4. P-glycoprotein in acute nonlymphoblastic leukemia and in the blastic crisis of myeloid leukemia.

5. Increased P-glycoprotein expression and multidrug-resistant gene (mdr1) amplification are infrequently found in fresh acute leukemia cells. Sequential analysis of 15 cases at initial presentation and relapsed stage.

6. Detection of P-glycoprotein in human leukemias using monoclonal antibodies.

7. Classification of chronic granulomatous disease on the basis of monoclonal antibody-defined surface cytochrome b deficiency.

8. Expression of the mdr-1/P-170 gene in patients with acute lymphoblastic leukemia.

9. Detection of multidrug resistance markers, P-glycoprotein and mdr1 mRNA, in human leukemia cells.

10. Detection of a multidrug resistant phenotype in acute non-lymphoblastic leukaemia.

1. Flow cytometric analysis of P-glycoprotein in normal and leukemic cells.

2. In vitro anthracycline cross-resistance pattern in childhood acute lymphoblastic leukaemia.