Literature DB >> 1674498

Physical and genetic mapping of a novel chromosome 19 ERCC1 marker showing close linkage with myotonic dystrophy.

G Shutler1, A E MacKenzie, H Brunner, B Wieringa, P de Jong, F P Lohman, S Leblond, J Bailly, R G Korneluk.   

Abstract

Recent genetic linkage analyses have mapped the myotonic dystrophy locus to the region of 19q13.2-13.3 lying distal to the gene for creatine kinase subunit M (CKM). The human excision repair gene ERCC1 has also been mapped to this region of chromosome 19. A novel polymorphic DNA marker, pEO.8, has been isolated from a chromosome 19 ERCC1-containing cosmid that maps to a 300-kb NotI fragment encompassing both CKM and ERCC1. Genetic linkage analysis reveals close linkage between pEO.8 and myotonic dystrophy (DM) (zmax = 19.3, theta max = 0.01). Analysis of two key recombinant events suggests a mapping of DM distal to pEO.8 and CKM.

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Year:  1991        PMID： 1674498     DOI： 10.1016/0888-7543(91)90416-c

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  8 in total

1.  A frequent HincII polymorphism identified by the human chromosome 19q13.3 probe pKEX0.8 (D19S118).

Authors:  C Tsilfidis; G Shutler; M Mahadevan; R G Korneluk
Journal:  Nucleic Acids Res       Date:  1991-03-11       Impact factor: 16.971

2.  RFLP identified by the probe pKE0.6 (D19S117) at human chromosome 19q13.3.

Authors:  G Shutler; C Tsilfidis; S Leblond; R G Korneluk
Journal:  Nucleic Acids Res       Date:  1991-03-11       Impact factor: 16.971

3.  An SstI RFLP detected by the probe pKE2.1 (D19S116) localized to human chromosome 19q13.3.

Authors:  C Tsilfidis; G Shutler; S Leblond; R G Korneluk
Journal:  Nucleic Acids Res       Date:  1991-03-11       Impact factor: 16.971

4.  An insertion polymorphism identified by the probe pE0.8 (D19S115) at 19q13.3.

Authors:  G Shutler; S Leblond; J Bailly; A E MacKenzie; C Tsilfidis; R G Korneluk
Journal:  Nucleic Acids Res       Date:  1991-03-11       Impact factor: 16.971

5.  A three allele insertion polymorphism is identified by the human chromosome 19q13.3 probe pKBE0.8 (D19S119).

Authors:  R G Korneluk; C Tsilfidis; G Shutler; M Mahadevan; J Bailly; L C Surh
Journal:  Nucleic Acids Res       Date:  1991-03-11       Impact factor: 16.971

6.  Linkage disequilibrium detected between myotonic dystrophy and the anonymous marker D19S63 in the Spanish population.

Authors:  A Cobo; D Grinberg; S Balcells; L Vilageliu; R Gonzàlez-Duarte; M Baiget
Journal:  Hum Genet       Date:  1992-05       Impact factor: 4.132

7.  D19S51 is closely linked with and maps distal to the myotonic dystrophy locus on 19q.

Authors:  C Tsilfidis; A E MacKenzie; G Shutler; S Leblond; J Bailly; K Johnson; R Williamson; J Siegel-Bartelt; R G Korneluk; P Shelbourne
Journal:  Am J Hum Genet       Date:  1991-11       Impact factor: 11.025

8.  The 1.5-Mb region spanning the myotonic dystrophy locus shows uniform recombination frequency.

Authors:  G G Shutler; A E MacKenzie; R G Korneluk
Journal:  Am J Hum Genet       Date:  1994-01       Impact factor: 11.025
  8 in total

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