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Literature DB >> 16742560

Effect of alloxan-diabetes on multiple forms of hexokinase in adipose tissue and lung.

P McLean¹, J Brown, E Walters, K Greenslade.

Abstract

Comparison has been made of the effect of alloxan-diabetes on the multiple forms of hexokinase (EC 2.7.1.1) in adipose tissue and lung. Types I and II hexokinase were distinguished in adipose tissue by their different stabilities to heat treatment, which made it possible to determine the activity of each form spectrophotometrically; additional confirmatory evidence was obtained from starch-gel electrophoresis. Type II hexokinase was markedly depressed in adipose tissue from alloxan-diabetic rats. Lung contained types I, II and III hexokinase, type I predominating. There was no significant change in the pattern of these multiple forms of hexokinase in lung from alloxan-diabetic rats. These results are discussed in relation to current ideas that the insulin-sensitivity of a tissue may be correlated with the content of type II hexokinase.

Entities: Chemical Disease Gene Species

Year: 1967 PMID： 16742560 PMCID： PMC1198455 DOI： 10.1042/bj1051301

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

19 in total

1. EFFECTS OF DIET AND INSULIN ON GLUCOSE-ADENOSINE TRIPHOSPHATE PHOSPHOTRANSFERASES OF RAT LIVER.

Authors: C SHARMA; R MANJESHWAR; S WEINHOUSE
Journal: J Biol Chem Date: 1963-12 Impact factor: 5.157

2. ON THE PRESENCE OF TWO SOLUBLE GLUCOSE-PHOSPHORYLATING ENZYMES IN ADULT LIVER AND THE DEVELOPMENT OF ONE OF THESE AFTER BIRTH.

Authors: D G WALKER
Journal: Biochim Biophys Acta Date: 1963-10-01

3. GLUCOKINASE OF RABBIT LIVER.

Authors: J SALAS; M SALAS; E VINUELA; A SOLS
Journal: J Biol Chem Date: 1965-03 Impact factor: 5.157

Review 4. SOME EFFECTS OF HORMONES ON THE METABOLISM OF ADIPOSE TISSUE.

Authors: E G BALL; R L JUNGAS
Journal: Recent Prog Horm Res Date: 1964

5. Insulin and metabolism of fatty acids.

Authors: S J FOLLEY; A L GREENBAUM
Journal: Br Med Bull Date: 1960-09 Impact factor: 4.291

6. Effect of insulin in vitro in pathways of glucose utilization, other than Embden-Meyerhof, in rat mammary gland.

Authors: S ABRAHAM; P CADY; I L CHAIKOFF
Journal: J Biol Chem Date: 1957-02 Impact factor: 5.157

7. Studies on rat adipose tissue in vitro. II. Effects of insulin on the metabolism of specifically labeled glucose.

Authors: A I WINEGRAD; A E RENOLD
Journal: J Biol Chem Date: 1958-08 Impact factor: 5.157

8. Levels of enzymes of the direct oxidative pathway of carbohydrate metabolism in mammalian tissues and tumours.

Authors: G E GLOCK; P McLEAN
Journal: Biochem J Date: 1954-01 Impact factor: 3.857

9. The role of glucokinase in the phosphorylation of glucose by rat liver.

Authors: D G Walker; S Rao
Journal: Biochem J Date: 1964-02 Impact factor: 3.857

10. Multiple molecular forms of ATP:hexose 6-phosphotransferase from rat liver.

Authors: C González; T Ureta; R Sánchez; H Niemeyer
Journal: Biochem Biophys Res Commun Date: 1964-07-01 Impact factor: 3.575

11 in total

1. Study of the metabolism in vitro of glucose in the rat epididymal fat tissue. Stimulating effect of palmitic acid.

Authors: N Zaragoza; J P Felber
Journal: Diabetologia Date: 1969-10 Impact factor: 10.122

2. The pentose phosphate pathway of glucose metabolism. Hormonal and dietary control of the oxidative nd non-oxidative reactions and related enzymes of the cycle in adipose tissue.

Authors: K A Gumaa; F Novello; P McLean
Journal: Biochem J Date: 1969-09 Impact factor: 3.857

3. Glycolytic enzymes in adipose tissue of adult diabetics.

Authors: D J Galton; J P Wilson
Journal: Br Med J Date: 1970-08-22

4. The effect of dietary and hormonal conditions on the activities of glycolytic enzymes in rat epididymal adipose tissue.

Authors: E D Saggerson; A L Greenbaum
Journal: Biochem J Date: 1969-11 Impact factor: 3.857

5. Antihyperlipidemic effect of bis-1,7-(2-hydroxyphenyl)-hepta-1,6-diene-3,5-dione, a curcumin analog, on nicotine and streptozotocin treated rats.

Authors: Bandugula Venkata Reddy; J Sivagama Sundari; Elumalai Balamurugan; Venugopal Padmanabhan Menon
Journal: Mol Cell Biochem Date: 2009-09-30 Impact factor: 3.396

6. Glucose metabolism in the mucosa of the small intestine. A study of hexokinase activity.

Authors: L M Srivastava; P Shakespeare; G Hübscher
Journal: Biochem J Date: 1968-08 Impact factor: 3.857

7. The effect of anti-insulin serum and alloxan-diabetes on the distribution and multiple forms of hexokinase in lactating rat mammary gland.

Authors: E Walters; P McLean
Journal: Biochem J Date: 1968-10 Impact factor: 3.857

8. Glucose metabolism in the mucosa of the small intestine. The effect of glucose on hexokinase activity.

Authors: P Shakespeare; L M Srivastava; G Hübscher
Journal: Biochem J Date: 1969-01 Impact factor: 3.857

Review 9. Role of monosaccharide transport proteins in carbohydrate assimilation, distribution, metabolism, and homeostasis.

Authors: Anthony J Cura; Anthony Carruthers
Journal: Compr Physiol Date: 2012-04 Impact factor: 9.090

10. The pentose phosphate pathway of glucose metabolism. Influence of a growth-hormone-secreting pituitary tumour on the oxidative and non-oxidative reactions of the cycle in liver.

Authors: K A Gumaa; R M MacLeod; P McLean
Journal: Biochem J Date: 1969-06 Impact factor: 3.857