Literature DB >> 1674171

Involvement of lymphocyte function-associated antigen-1 (LFA-1) in HIV infection: inhibition by monoclonal antibody.

J E Hansen1, C Nielsen, L R Mathiesen, J O Nielsen.   

Abstract

Monoclonal antibodies (MAbs) against the alpha- and beta-chain of lymphocyte-associated antigen-1 (LFA-1) were examined for inhibition of HIV-1 infection in vitro. Infection of the T cell line MT4 and the monocytic cell line U937 by isolates HTLVIIIB and SSI-002, respectively was inhibited in a concentration dependent manner by MAb against the beta-chain but not against the alpha-chain. No cross-reactivity was found between MAb against LFA-1 and against the CD4 receptor (MAb Leu3a). MAbs against the beta-chain and the CD4 receptor were found to act synergistically in inhibiting HIV infection. These data indicate that the beta-chain of LFA-1 in addition to the CD4 receptor may be involved in HIV infection in vitro.

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Year:  1991        PMID： 1674171     DOI： 10.3109/00365549109023371

Source DB:  PubMed          Journal:  Scand J Infect Dis        ISSN： 0036-5548


  7 in total

1.  Infection of peripheral blood mononuclear cells and cell lines by cell-free human T-cell lymphoma/leukemia virus type I.

Authors:  N Fan; J Gavalchin; B Paul; K H Wells; M J Lane; B J Poiesz
Journal:  J Clin Microbiol       Date:  1992-04       Impact factor: 5.948

2.  Antibody to adhesion molecule LFA-1 enhances plasma neutralization of human immunodeficiency virus type 1.

Authors:  M B Gomez; J E Hildreth
Journal:  J Virol       Date:  1995-08       Impact factor: 5.103

3.  Broadly neutralizing antibodies targeted to mucin-type carbohydrate epitopes of human immunodeficiency virus.

Authors:  J E Hansen; C Nielsen; M Arendrup; S Olofsson; L Mathiesen; J O Nielsen; H Clausen
Journal:  J Virol       Date:  1991-12       Impact factor: 5.103

Review 4.  Pathogenesis of human immunodeficiency virus infection.

Authors:  J A Levy
Journal:  Microbiol Rev       Date:  1993-03

5.  Expression patterns of Fc gamma receptors, HLA-DR and selected adhesion molecules on monocytes from normal and HIV-infected individuals.

Authors:  C Locher; G Vanham; L Kestens; M Kruger; J L Ceuppens; J Vingerhoets; P Gigase
Journal:  Clin Exp Immunol       Date:  1994-10       Impact factor: 4.330

6.  Cellular CD44S as a determinant of human immunodeficiency virus type 1 infection and cellular tropism.

Authors:  C S Dukes; Y Yu; E D Rivadeneira; D L Sauls; H X Liao; B F Haynes; J B Weinberg
Journal:  J Virol       Date:  1995-07       Impact factor: 5.103

Review 7.  Cellular kinases incorporated into HIV-1 particles: passive or active passengers?

Authors:  Charline Giroud; Nathalie Chazal; Laurence Briant
Journal:  Retrovirology       Date:  2011-09-02       Impact factor: 4.602
  7 in total

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