Literature DB >> 1719230

Broadly neutralizing antibodies targeted to mucin-type carbohydrate epitopes of human immunodeficiency virus.

J E Hansen1, C Nielsen, M Arendrup, S Olofsson, L Mathiesen, J O Nielsen, H Clausen.   

Abstract

The cancer-related mucin-type carbohydrate neoantigen Tn was found on gp160 and gp120 of human immunodeficiency virus (HIV). Immunoglobulin G (IgG) and IgM monoclonal antibodies (MAbs) against Tn neutralized infection with cell-free virus and blocked fusion between HIV-infected and uninfected cells. This inhibition was found in infection of both lymphocytic cells and monocytoid cells. Viruses tested included six HIV-1 and five HIV-2 isolates propagated in different cells, as well as infectious plasma from AIDS patients. The antiviral effect of anti-Tn MAbs occurred by specific binding of the MAb to the virus; this binding was inhibitable by pure Tn antigen, and indications were found that this inhibition occurred at a pre-entry step. Boosting the naturally occurring low-titer anti-Tn activity may be of prophylactic value, as suggested by the in vitro neutralization found in this study.

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Year:  1991        PMID： 1719230      PMCID： PMC250685     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  31 in total

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Journal:  J Virol       Date:  1988-03       Impact factor: 5.103

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Journal:  Science       Date:  1985-08-09       Impact factor: 47.728

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Authors:  F Clavel; M Guyader; D Guétard; M Sallé; L Montagnier; M Alizon
Journal:  Nature       Date:  1986 Dec 18-31       Impact factor: 49.962

6.  Genetic analysis of a new subgroup of human and simian T-lymphotropic retroviruses: HTLV-IV, LAV-2, SBL-6669, and STLV-IIIAGM.

Authors:  G Franchini; E Collalti; S K Arya; E M Fenyö; G Biberfeld; J F Zagury; P J Kanki; F Wong-Staal; R C Gallo
Journal:  AIDS Res Hum Retroviruses       Date:  1987       Impact factor: 2.205

7.  Binding of HTLV-III/LAV to T4+ T cells by a complex of the 110K viral protein and the T4 molecule.

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Journal:  Science       Date:  1986-01-24       Impact factor: 47.728

8.  Neutralizing antibodies to an immunodominant envelope sequence do not prevent gp120 binding to CD4.

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Journal:  J Virol       Date:  1988-11       Impact factor: 5.103

9.  Preparation and characterization of monoclonal antibodies directed to the tumor-associated O-linked sialosyl-2----6 alpha-N-acetylgalactosaminyl (sialosyl-Tn) epitope.

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Journal:  Cancer Res       Date:  1988-04-15       Impact factor: 12.701

10.  Human cytomegalovirus induces stage-specific embryonic antigen 1 in differentiating human teratocarcinoma cells and fibroblasts.

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Journal:  J Exp Med       Date:  1989-04-01       Impact factor: 14.307
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  30 in total

Review 1.  Cellular and humoral antigenic epitopes in HIV and SIV.

Authors:  D F Nixon; K Broliden; G Ogg; P A Broliden
Journal:  Immunology       Date:  1992-08       Impact factor: 7.397

2.  Resolving conflicting data on expression of the Tn antigen and implications for clinical trials with cancer vaccines.

Authors:  Qian Li; Miriam R Anver; Donna O Butcher; Jeffrey C Gildersleeve
Journal:  Mol Cancer Ther       Date:  2009-04       Impact factor: 6.261

3.  NetOglyc: prediction of mucin type O-glycosylation sites based on sequence context and surface accessibility.

Authors:  J E Hansen; O Lund; N Tolstrup; A A Gooley; K L Williams; S Brunak
Journal:  Glycoconj J       Date:  1998-02       Impact factor: 2.916

4.  Serum glycan-binding IgG antibodies in HIV-1 infection and during the development of broadly neutralizing responses.

Authors:  Cathrine Scheepers; Sudipa Chowdhury; W Shea Wright; Christopher T Campbell; Nigel J Garrett; Quarraisha Abdool Karim; Salim S Abdool Karim; Penny L Moore; Jeffrey C Gildersleeve; Lynn Morris
Journal:  AIDS       Date:  2017-10-23       Impact factor: 4.177

5.  Epitopic structure of Tn glycophorin A for an anti-Tn antibody (MLS 128).

Authors:  H Nakada; M Inoue; Y Numata; N Tanaka; I Funakoshi; S Fukui; A Mellors; I Yamashina
Journal:  Proc Natl Acad Sci U S A       Date:  1993-03-15       Impact factor: 11.205

6.  Neutralization sensitivity of human immunodeficiency virus type 1 is determined in part by the cell in which the virus is propagated.

Authors:  L S Sawyer; M T Wrin; L Crawford-Miksza; B Potts; Y Wu; P A Weber; R D Alfonso; C V Hanson
Journal:  J Virol       Date:  1994-03       Impact factor: 5.103

7.  Alterations in potential sites for glycosylation predominate during evolution of the simian immunodeficiency virus envelope gene in macaques.

Authors:  J Overbaugh; L M Rudensey
Journal:  J Virol       Date:  1992-10       Impact factor: 5.103

8.  Glycosylation patterns of HIV-1 gp120 depend on the type of expressing cells and affect antibody recognition.

Authors:  Milan Raska; Kazuo Takahashi; Lydie Czernekova; Katerina Zachova; Stacy Hall; Zina Moldoveanu; Matt C Elliott; Landon Wilson; Rhubell Brown; Dagmar Jancova; Stephen Barnes; Jana Vrbkova; Milan Tomana; Phillip D Smith; Jiri Mestecky; Matthew B Renfrow; Jan Novak
Journal:  J Biol Chem       Date:  2010-05-03       Impact factor: 5.157

9.  An O-linked carbohydrate neutralization epitope of HIV-1 gp 120 is expressed by HIV-1 env gene recombinant vaccinia virus.

Authors:  J E Hansen; H Clausen; S L Hu; J O Nielsen; S Olofsson
Journal:  Arch Virol       Date:  1992       Impact factor: 2.574

Review 10.  Pathogenesis of human immunodeficiency virus infection.

Authors:  J A Levy
Journal:  Microbiol Rev       Date:  1993-03
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