| Literature DB >> 16740119 |
R John Ellis1, Allen P Minton.
Abstract
The generic tendency of proteins to aggregate into non-functional, and sometimes cytotoxic, structures poses a universal problem for all types of cell. This tendency is greatly exacerbated by the high total concentration of macromolecules found within most intracellular compartments, a phenomenon referred to as macromolecular crowding. This review discusses the quantitative effects of crowding on protein aggregation and the role of molecular chaperones in combating this problem.Entities:
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Year: 2006 PMID： 16740119 DOI： 10.1515/BC.2006.064
Source DB: PubMed Journal: Biol Chem ISSN： 1431-6730 Impact factor: 3.915