OBJECTIVE: This study tested the relationships between perceived control and biological processes relevant to asthma in children. METHODS: Forty children diagnosed with asthma completed the Children's Health Locus of Control (CHLC) scale. Participants also completed pulmonary function testing, measuring forced vital capacity (FVC), and forced expiratory volume in 1 second (FEV1). Blood was drawn to assess immune markers associated with asthma. Specifically, stimulated production of the cytokines interleukin 4 (IL-4), interleukin-5 (IL-5), interleukin-13 (IL-13), interferon-gamma (IFN-gamma), as well as eosinophil count, was measured. At home, participants completed peak expiratory flow rate (PEFR) measures to monitor their daily pulmonary function. RESULTS: Higher levels of perceived control were associated with significantly better FVC, FEV1, and PEFR variability. Higher levels of perceived control were also associated with decreased production of asthma-related cytokines, including IL-4, IL-5, and IL-13. CONCLUSION: These results suggest that psychological processes such as perceived control may play an important role in asthma-related biological processes among children with asthma.
OBJECTIVE: This study tested the relationships between perceived control and biological processes relevant to asthma in children. METHODS: Forty children diagnosed with asthma completed the Children's Health Locus of Control (CHLC) scale. Participants also completed pulmonary function testing, measuring forced vital capacity (FVC), and forced expiratory volume in 1 second (FEV1). Blood was drawn to assess immune markers associated with asthma. Specifically, stimulated production of the cytokines interleukin 4 (IL-4), interleukin-5 (IL-5), interleukin-13 (IL-13), interferon-gamma (IFN-gamma), as well as eosinophil count, was measured. At home, participants completed peak expiratory flow rate (PEFR) measures to monitor their daily pulmonary function. RESULTS: Higher levels of perceived control were associated with significantly better FVC, FEV1, and PEFR variability. Higher levels of perceived control were also associated with decreased production of asthma-related cytokines, including IL-4, IL-5, and IL-13. CONCLUSION: These results suggest that psychological processes such as perceived control may play an important role in asthma-related biological processes among children with asthma.
Authors: Janice K Kiecolt-Glaser; Kathi L Heffner; Ronald Glaser; William B Malarkey; Kyle Porter; Cathie Atkinson; Bryon Laskowski; Stanley Lemeshow; Gailen D Marshall Journal: Psychoneuroendocrinology Date: 2009-01-15 Impact factor: 4.905
Authors: Sandra D Cortina; Dennis Drotar; Mark Ericksen; Mark Lindsey; Tia L Patterson; Jocelyn M Biagini Myers; Melinda Butsch Kovacic; Gurjit K Khurana Hershey Journal: J Pediatr Date: 2011-02-15 Impact factor: 4.406
Authors: Debra K Moser; Barbara Riegel; Sharon McKinley; Lynn V Doering; Hendrika Meischke; Seongkum Heo; Terry A Lennie; Kathleen Dracup Journal: Nurs Res Date: 2009 Jan-Feb Impact factor: 2.381
Authors: Judith G Chipperfield; Raymond P Perry; Reinhard Pekrun; Petra Barchfeld; Frieder R Lang; Jeremy M Hamm Journal: PLoS One Date: 2016-03-14 Impact factor: 3.240