OBJECTIVES: To determine the relationship between single nucleotide polymorphisms in candidate genes associated with multiple asthma phenotypes and health-related quality of life (HRQOL). STUDY DESIGN: A cross-sectional study was conducted at a pediatric hospital in 275 school-aged children diagnosed with asthma and their caregivers. Genomic DNA was obtained from children, and caregivers completed a measure of their child's HRQOL. Analysis of variance was used to investigate the association between single nucleotide polymorphisms and HRQOL. RESULTS: Children homozygous for the major variant at IL-4RA rs 1805010 had significantly better HRQOL than their counterparts. Significant associations with pulmonary function were not observed. CONCLUSIONS: Genes associated with asthma phenotype can be associated with HRQOL at least partly independent of pulmonary function.
OBJECTIVES: To determine the relationship between single nucleotide polymorphisms in candidate genes associated with multiple asthma phenotypes and health-related quality of life (HRQOL). STUDY DESIGN: A cross-sectional study was conducted at a pediatric hospital in 275 school-aged children diagnosed with asthma and their caregivers. Genomic DNA was obtained from children, and caregivers completed a measure of their child's HRQOL. Analysis of variance was used to investigate the association between single nucleotide polymorphisms and HRQOL. RESULTS:Children homozygous for the major variant at IL-4RA rs 1805010 had significantly better HRQOL than their counterparts. Significant associations with pulmonary function were not observed. CONCLUSIONS: Genes associated with asthma phenotype can be associated with HRQOL at least partly independent of pulmonary function.
Authors: Peter H Michelson; Larry W Williams; Daniel K Benjamin; Amber E Barnato Journal: Ann Allergy Asthma Immunol Date: 2009-11 Impact factor: 6.347
Authors: Paul J Sharek; Michelle L Mayer; Lisa Loewy; Thomas N Robinson; Richard S Shames; Dale T Umetsu; David A Bergman Journal: Pediatrics Date: 2002-10 Impact factor: 7.124
Authors: Juan R Ordoñana; Meike Bartels; Dorret I Boomsma; David Cella; Miriam Mosing; Joao R Oliveira; Donald L Patrick; Ruut Veenhoven; Gert G Wagner; Mirjam A G Sprangers Journal: Qual Life Res Date: 2012-10-10 Impact factor: 4.147