Literature DB >> 1673794

Characterization of melanotropin-release-inhibiting factor (melanostatin) from frog brain: homology with human neuropeptide Y.

N Chartrel1, J M Conlon, J M Danger, A Fournier, M C Tonon, H Vaudry.   

Abstract

A polypeptide was purified from frog brain extracts on the basis of its ability to inhibit alpha-melanotropin release from perifused frog neurointermediate lobes. Based on Edman degradation, amino acid analysis, and peptide mapping, the primary structure of this frog melanotropin-release-inhibiting factor (melanostatin) was determined to be H-Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro-Ala-Glu-Asp-Met- Ala-Lys-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg- Tyr-NH2 . Frog melanostatin belongs to the pancreatic polypeptide/neuropeptide Y/peptide YY family, and the structure of this peptide differs from that of human neuropeptide Y by only one amino acid substitution in position 19. A synthetic replicate of frog melanostatin is coeluted with the native peptide on HPLC and is highly potent in inhibiting alpha-melanotropin secretion in vitro (IC50 = 60 nM).

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Year:  1991        PMID： 1673794      PMCID： PMC51553          DOI： 10.1073/pnas.88.9.3862

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  34 in total

1.  Inhibition of MSH release in frogs by direct application of L-proplyl-L-leucylglycinamide to the pituitary.

Authors:  A J Kastin; A V Schally; S Viosca
Journal:  Proc Soc Exp Biol Med       Date:  1971-09

2.  Immuno-enzyme cytochemical demonstration of mesotocinergic nerve fibres in the pars intermedia of the amphibian hypophysis.

Authors:  K Dierickx; F Vandesande
Journal:  Cell Tissue Res       Date:  1976-10-22       Impact factor: 5.249

3.  Preparation and use of benzhydrylamine polymers in peptide synthesis. II. Syntheses of thyrotropin releasing hormone, thyrocalcitonin 26-32, and eledoisin.

Authors:  P G Pietta; P F Cavallo; K Takahashi; G R Marshall
Journal:  J Org Chem       Date:  1974-01-11       Impact factor: 4.354

4.  Isolation and characterization of peptide YY (PYY), a candidate gut hormone that inhibits pancreatic exocrine secretion.

Authors:  K Tatemoto
Journal:  Proc Natl Acad Sci U S A       Date:  1982-04       Impact factor: 11.205

5.  Purification and characterization of human neuropeptide Y from adrenal-medullary phaeochromocytoma tissue.

Authors:  R Corder; P C Emson; P J Lowry
Journal:  Biochem J       Date:  1984-05-01       Impact factor: 3.857

6.  Oxytocin-immunoreactive nerve fibers in the pars intermedia of the pituitary in the rabbit and hare.

Authors:  S Schimchowitsch; M E Stoeckel; M J Klein; J C Garaud; G Schmitt; A Porte
Journal:  Cell Tissue Res       Date:  1983       Impact factor: 5.249

7.  [Stimulatory control by oxytocin (or an analog peptide) of the pituitary intermediate lobe in rabbits. Inhibitory role of serotonin].

Authors:  S Schimchowitsch; M E Stoeckel; G Schmitt; A Porte
Journal:  C R Acad Sci III       Date:  1985

8.  Regulation of formation and proposed structure of the factor inhibiting the release of melanocyte-stimulating hormone.

Authors:  M E Celis; S Taleisnik; R Walter
Journal:  Proc Natl Acad Sci U S A       Date:  1971-07       Impact factor: 11.205

9.  The failure of L-prolyl-L-leucylglycinamide to inhibit the release of alpha-melanocyte-stimulating hormone in the rat.

Authors:  A J Thody; C H Lever de Vries; F J Tilders
Journal:  Acta Endocrinol (Copenh)       Date:  1980-03

10.  The dopamine receptor in the intermediate lobe of the rat pituitary gland: pharmacological characterization.

Authors:  M Munemura; T E Cote; K Tsuruta; R L Eskay; J W Kebabian
Journal:  Endocrinology       Date:  1980-12       Impact factor: 4.736
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  14 in total

1.  Occurrence of two somatostatin variants in the frog brain: characterization of the cDNAs, distribution of the mRNAs, and receptor-binding affinities of the peptides.

Authors:  H Tostivint; I Lihrmann; C Bucharles; D Vieau; Y Coulouarn; A Fournier; J M Conlon; H Vaudry
Journal:  Proc Natl Acad Sci U S A       Date:  1996-10-29       Impact factor: 11.205

2.  Neurotrophic activity of pituitary adenylate cyclase-activating polypeptide on rat cerebellar cortex during development.

Authors:  D Vaudry; B J Gonzalez; M Basille; A Fournier; H Vaudry
Journal:  Proc Natl Acad Sci U S A       Date:  1999-08-03       Impact factor: 11.205

3.  Strong evolutionary conservation of neuropeptide Y: sequences of chicken, goldfish, and Torpedo marmorata DNA clones.

Authors:  A G Blomqvist; C Söderberg; I Lundell; R J Milner; D Larhammar
Journal:  Proc Natl Acad Sci U S A       Date:  1992-03-15       Impact factor: 11.205

4.  Identification of 26RFa, a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity.

Authors:  Nicolas Chartrel; Cynthia Dujardin; Youssef Anouar; Jérôme Leprince; Annick Decker; Stefan Clerens; Jean-Claude Do-Régo; Frans Vandesande; Catherine Llorens-Cortes; Jean Costentin; Jean-Claude Beauvillain; Hubert Vaudry
Journal:  Proc Natl Acad Sci U S A       Date:  2003-12-01       Impact factor: 11.205

5.  A-type potassium current modulated by A1 adenosine receptor in frog melanotrophs.

Authors:  Y A Mei; E Louiset; H Vaudry; L Cazin
Journal:  J Physiol       Date:  1995-12-01       Impact factor: 5.182

6.  Functional characterization of a nonclassical nicotine receptor associated with inositolphospholipid breakdown and mobilization of intracellular calcium pools.

Authors:  M Garnier; M Lamacz; M C Tonon; H Vaudry
Journal:  Proc Natl Acad Sci U S A       Date:  1994-11-22       Impact factor: 11.205

7.  Frog diazepam-binding inhibitor: peptide sequence, cDNA cloning, and expression in the brain.

Authors:  I Lihrmann; J C Plaquevent; H Tostivint; R Raijmakers; M C Tonon; J M Conlon; H Vaudry
Journal:  Proc Natl Acad Sci U S A       Date:  1994-07-19       Impact factor: 11.205

8.  Skin peptide tyrosine-tyrosine, a member of the pancreatic polypeptide family: isolation, structure, synthesis, and endocrine activity.

Authors:  A Mor; N Chartrel; H Vaudry; P Nicolas
Journal:  Proc Natl Acad Sci U S A       Date:  1994-10-25       Impact factor: 11.205

9.  Melanostatin (NPY) inhibited electrical activity in frog melanotrophs through modulation of K+, Na+ and Ca2+ currents.

Authors:  J A Valentijn; H Vaudry; W Kloas; L Cazin
Journal:  J Physiol       Date:  1994-03-01       Impact factor: 5.182

10.  Terminal nerve-derived neuropeptide y modulates physiological responses in the olfactory epithelium of hungry axolotls (Ambystoma mexicanum).

Authors:  Angela Mousley; Gianluca Polese; Nikki J Marks; Heather L Eisthen
Journal:  J Neurosci       Date:  2006-07-19       Impact factor: 6.709
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