Literature DB >> 16737323

Two novel diastereoselective three-component reactions of alkenes or 3,4-dihydro-(2H)-pyran with urea/thiourea-aldehyde mixtures: [4 + 2] cycloaddition vs Biginelli-type reaction.

Yulin Zhu1, Shenlin Huang, Jieping Wan, Lei Yan, Yuanjiang Pan, Anxin Wu.   

Abstract

Two novel diastereoselective three-component reactions of alkenes or 3,4-dihydro-(2H)-pyran with urea/thiourea-aldehyde mixtures are described. [reaction: see text]

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Year:  2006        PMID： 16737323     DOI： 10.1021/ol060874b

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  3 in total

1.  Highly efficient and catalyst-free synthesis of substituted thioureas in water.

Authors:  Shi-Feng Gan; Jie-Ping Wan; Yuan-Jiang Pan; Cui-Rong Sun
Journal:  Mol Divers       Date:  2011-01-11       Impact factor: 2.943

2.  Targeting the BACE1 Active Site Flap Leads to a Potent Inhibitor That Elicits Robust Brain Aβ Reduction in Rodents.

Authors:  Yong-Jin Wu; Jason Guernon; Fukang Yang; Lawrence Snyder; Jianliang Shi; Andrea Mcclure; Ramkumar Rajamani; Hyunsoo Park; Alicia Ng; Hal Lewis; ChiehYing Chang; Dan Camac; Jeremy H Toyn; Michael K Ahlijanian; Charles F Albright; John E Macor; Lorin A Thompson
Journal:  ACS Med Chem Lett       Date:  2016-01-11       Impact factor: 4.345

3.  A new paradigm for designing ring construction strategies for green organic synthesis: implications for the discovery of multicomponent reactions to build molecules containing a single ring.

Authors:  John Andraos
Journal:  Beilstein J Org Chem       Date:  2016-11-16       Impact factor: 2.883
  3 in total

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