Literature DB >> 16737293

Total synthesis of (+/-)-paeonilide.

Chenying Wang1, Jikai Liu, Yanhua Ji, Jingfeng Zhao, Liang Li, Hongbin Zhang.   

Abstract

The total synthesis of paeonilide, a natural anti-PAF (platelet-activating factor) new skeleton monoterpenoid with an IC(50) value of 8 microg/mL, was achieved in 16 steps with 15% overall yield from commercially available 2-hydroxy-4-methylacetophenone. [reaction: see text]

Entities:  

Mesh：

Substances：

Year:  2006        PMID： 16737293     DOI： 10.1021/ol060382z

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  3 in total

1.  Catalytic Hydroxycyclopropanol Ring-Opening Carbonylative Lactonization to Fused Bicyclic Lactones.

Authors:  Xinpei Cai; Weida Liang; Mingxin Liu; Xiating Li; Mingji Dai
Journal:  J Am Chem Soc       Date:  2020-07-27       Impact factor: 15.419

2.  Facile synthesis of (+/-)-paeonilide.

Authors:  Yuguo Du; Jun Liu; Robert J Linhardt
Journal:  J Org Chem       Date:  2007-04-06       Impact factor: 4.354

Review 3.  Synthesis of five- and six-membered cyclic organic peroxides: Key transformations into peroxide ring-retaining products.

Authors:  Alexander O Terent'ev; Dmitry A Borisov; Vera A Vil'; Valery M Dembitsky
Journal:  Beilstein J Org Chem       Date:  2014-01-08       Impact factor: 2.883
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.