Literature DB >> 16734458

Thiamin biosynthesis in eukaryotes: characterization of the enzyme-bound product of thiazole synthase from Saccharomyces cerevisiae and its implications in thiazole biosynthesis.

Abhishek Chatterjee1, Christopher T Jurgenson, Frank C Schroeder, Steven E Ealick, Tadhg P Begley.   

Abstract

The biosynthesis of thiamin pyrophosphate in eukaryotes is different from the prokaryotic biosynthesis and is poorly understood to date. Only one thiazole biosynthetic gene has been identified (Thi4 in Saccharomyces cerevisiae). Here we report the identification and characterization of a Thi4-bound metabolite that consists of the ADP adduct of 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid. The unexpected structure of this compound yields the first insights into the mechanism of thiamin thiazole biosynthesis in eukaryotes.

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Year:  2006        PMID： 16734458      PMCID： PMC2631426          DOI： 10.1021/ja061413o

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  11 in total

Review 1.  Current mechanistic understanding of thiamin diphosphate-dependent enzymatic reactions.

Authors:  Frank Jordan
Journal:  Nat Prod Rep       Date:  2003-04       Impact factor: 13.423

Review 2.  NAD+ surfaces again.

Authors:  Mathias Ziegler; Marc Niere
Journal:  Biochem J       Date:  2004-09-15       Impact factor: 3.857

3.  Mechanistic studies on thiamin phosphate synthase: evidence for a dissociative mechanism.

Authors:  J J Reddick; R Nicewonger; T P Begley
Journal:  Biochemistry       Date:  2001-08-28       Impact factor: 3.162

4.  A novel binding protein for a member of CyP40-type Cyclophilins: N.crassa CyPBP37, a growth and thiamine regulated protein homolog to yeast Thi4p.

Authors:  Pierre Faou; Maximilian Tropschug
Journal:  J Mol Biol       Date:  2003-10-31       Impact factor: 5.469

Review 5.  The new life of a centenarian: signalling functions of NAD(P).

Authors:  Felicitas Berger; María H Ramírez-Hernández; Mathias Ziegler
Journal:  Trends Biochem Sci       Date:  2004-03       Impact factor: 13.807

Review 6.  Structural biology of enzymes of the thiamin biosynthesis pathway.

Authors:  Ethan Settembre; Tadhg P Begley; Steven E Ealick
Journal:  Curr Opin Struct Biol       Date:  2003-12       Impact factor: 6.809

7.  Thiamin deficiency and brain disorders.

Authors:  Roger F Butterworth
Journal:  Nutr Res Rev       Date:  2003-12       Impact factor: 7.800

8.  Regulation of THI4 (MOL1), a thiamine-biosynthetic gene of Saccharomyces cerevisiae.

Authors:  U M Praekelt; K L Byrne; P A Meacock
Journal:  Yeast       Date:  1994-04       Impact factor: 3.239

9.  Thiamin biosynthesis in Saccharomyces cerevisiae. Origin of carbon-2 of the thiazole moiety.

Authors:  R L White; I D Spenser
Journal:  Biochem J       Date:  1979-05-01       Impact factor: 3.857

10.  Neurospora crassa CyPBP37: a cytosolic stress protein that is able to replace yeast Thi4p function in the synthesis of vitamin B1.

Authors:  Pierre Faou; Maximilian Tropschug
Journal:  J Mol Biol       Date:  2004-12-03       Impact factor: 5.469
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  19 in total

1.  A maize thiamine auxotroph is defective in shoot meristem maintenance.

Authors:  John B Woodward; N Dinuka Abeydeera; Debamita Paul; Kimberly Phillips; Maria Rapala-Kozik; Michael Freeling; Tadhg P Begley; Steven E Ealick; Paula McSteen; Michael J Scanlon
Journal:  Plant Cell       Date:  2010-10-22       Impact factor: 11.277

Review 2.  Cofactor biosynthesis--still yielding fascinating new biological chemistry.

Authors:  Tadhg P Begley; Abhishek Chatterjee; Jeremiah W Hanes; Amrita Hazra; Steven E Ealick
Journal:  Curr Opin Chem Biol       Date:  2008-04-02       Impact factor: 8.822

3.  High-resolution crystal structure of the eukaryotic HMP-P synthase (THIC) from Arabidopsis thaliana.

Authors:  Sandrine Coquille; Céline Roux; Angad Mehta; Tadhg P Begley; Teresa B Fitzpatrick; Stéphane Thore
Journal:  J Struct Biol       Date:  2013-10-23       Impact factor: 2.867

Review 4.  Vitamin and cofactor biosynthesis pathways in Plasmodium and other apicomplexan parasites.

Authors:  Sylke Müller; Barbara Kappes
Journal:  Trends Parasitol       Date:  2007-02-02

Review 5.  Thiamin biosynthesis: still yielding fascinating biological chemistry.

Authors:  Tadhg P Begley; Steven E Ealick; Fred W McLafferty
Journal:  Biochem Soc Trans       Date:  2012-06-01       Impact factor: 5.407

6.  A missing enzyme in thiamin thiazole biosynthesis: identification of TenI as a thiazole tautomerase.

Authors:  Amrita B Hazra; Ying Han; Abhishek Chatterjee; Yang Zhang; Rung-Yi Lai; Steven E Ealick; Tadhg P Begley
Journal:  J Am Chem Soc       Date:  2011-05-26       Impact factor: 15.419

7.  A "radical dance" in thiamin biosynthesis: mechanistic analysis of the bacterial hydroxymethylpyrimidine phosphate synthase.

Authors:  Abhishek Chatterjee; Amrita B Hazra; Sameh Abdelwahed; David G Hilmey; Tadhg P Begley
Journal:  Angew Chem Int Ed Engl       Date:  2010-11-08       Impact factor: 15.336

8.  Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily.

Authors:  Abhishek Chatterjee; Yue Li; Yang Zhang; Tyler L Grove; Michael Lee; Carsten Krebs; Squire J Booker; Tadhg P Begley; Steven E Ealick
Journal:  Nat Chem Biol       Date:  2008-10-26       Impact factor: 15.040

9.  Biosynthesis of the thiamin thiazole in Bacillus subtilis: identification of the product of the thiazole synthase-catalyzed reaction.

Authors:  Amrita Hazra; Abhishek Chatterjee; Tadhg P Begley
Journal:  J Am Chem Soc       Date:  2009-03-11       Impact factor: 15.419

10.  Structural similarities between thiamin-binding protein and thiaminase-I suggest a common ancestor.

Authors:  Erika V Soriano; Kanagalaghatta R Rajashankar; Jeremiah W Hanes; Shridhar Bale; Tadhg P Begley; Steven E Ealick
Journal:  Biochemistry       Date:  2008-01-05       Impact factor: 3.162
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