| Literature DB >> 16733517 |
L R Kidd1, A Coulibaly, T M Templeton, W Chen, L O Long, T Mason, C Bonilla, F Akereyeni, V Freeman, W Isaacs, C Ahaghotu, R A Kittles.
Abstract
Apoptosis is an essential physiological process that regulates cellular proliferation. Here, we explored the effect of DNA sequence variation within the BCL-2 gene on prostate cancer susceptibility in three clinical populations, consisting of 428 African Americans, 214 Jamaicans and 218 European Americans. We observed a 70% reduced risk for prostate cancer among the European Americans who had possessed two copies of a promoter variant -938C/A. Additionally, common BCL-2 haplotypes appeared to influence prostate cancer risk; however, studies in larger data sets are needed to confirm our findings. Our data suggest that inherited BCL-2 variants may be associated with a decrease in prostate cancer susceptibility.Entities:
Mesh：
Substances：
Year: 2006 PMID： 16733517 DOI： 10.1038/sj.pcan.4500884
Source DB: PubMed Journal: Prostate Cancer Prostatic Dis ISSN： 1365-7852 Impact factor: 5.554