OBJECTIVE: We previously observed a relative contralateral neglect by right parietal single-pulse TMS given 150 ms after visual stimulus presentation. Here we investigated the effects of parietal paired TMS in normal subjects performing a visuospatial task. METHODS: Thirteen right-handed healthy subjects underwent a line-length judgement task during single-pulse and paired (1, 3, 5, 10 ms ISIs) TMS, delivered on the right parietal cortex 150 ms after visual stimulus. RESULTS: Single pulse TMS over the right parietal cortex induced a significant rightward bias compared to the baseline condition. At 1 and 3 ms ISIs, paired-pulse TMS did not show any effect in comparison with single pulse TMS. More importantly, 5 ms ISI was able to restore baseline levels, thus inducing a significant improvement of the performance compared to single-pulse TMS and 1-3 ms ISIs. CONCLUSIONS: Paired TMS seems able to modulate activity of the right posterior parietal cortex in healthy subjects performing a cognitive visuospatial task.
OBJECTIVE: We previously observed a relative contralateral neglect by right parietal single-pulse TMS given 150 ms after visual stimulus presentation. Here we investigated the effects of parietal paired TMS in normal subjects performing a visuospatial task. METHODS: Thirteen right-handed healthy subjects underwent a line-length judgement task during single-pulse and paired (1, 3, 5, 10 ms ISIs) TMS, delivered on the right parietal cortex 150 ms after visual stimulus. RESULTS: Single pulse TMS over the right parietal cortex induced a significant rightward bias compared to the baseline condition. At 1 and 3 ms ISIs, paired-pulse TMS did not show any effect in comparison with single pulse TMS. More importantly, 5 ms ISI was able to restore baseline levels, thus inducing a significant improvement of the performance compared to single-pulse TMS and 1-3 ms ISIs. CONCLUSIONS: Paired TMS seems able to modulate activity of the right posterior parietal cortex in healthy subjects performing a cognitive visuospatial task.
Authors: Olga Lucia Gamboa; Alexandra Brito; Zachary Abzug; Tracy D'Arbeloff; Lysianne Beynel; Erik A Wing; Moritz Dannhauer; Hannah Palmer; Susan A Hilbig; Courtney A Crowell; Sicong Liu; Rachel Donaldson; Roberto Cabeza; Simon W Davis; Angel V Peterchev; Marc A Sommer; Lawrence G Appelbaum Journal: Neurosci Lett Date: 2020-05-13 Impact factor: 3.046
Authors: Ela B Plow; Zaira Cattaneo; Thomas A Carlson; George A Alvarez; Alvaro Pascual-Leone; Lorella Battelli Journal: Front Hum Neurosci Date: 2014-04-17 Impact factor: 3.169
Authors: Raffaella Ricci; Adriana Salatino; Xingbao Li; Agnes P Funk; Sarah L Logan; Qiwen Mu; Kevin A Johnson; Daryl E Bohning; Mark S George Journal: Front Hum Neurosci Date: 2012-12-17 Impact factor: 3.169