| Literature DB >> 16723176 |
Patricia Gorak-Stolinska1, Rosemary E Weir, Sian Floyd, Maeve K Lalor, Sally Stenson, Keith Branson, Rose Blitz, Sarah Luke, Bernadette Nazareth, Anne Ben-Smith, Paul E M Fine, Hazel M Dockrell.
Abstract
The immunogenicity and reactogenicity, in British schoolchildren, of the newly introduced Danish-SSI 1331 BCG vaccine was compared with that of the previously used Glaxo-Evans 1077 BCG vaccine. Interferon-gamma (IFN-gamma) response to M. tuberculosis purified protein derivative (M.tb PPD) in a 6-day whole blood assay and delayed type hypersensitivity (DTH) to tuberculin PPD were determined before and 1 year after receiving BCG or no vaccination. Scar size was measured 1 year after vaccination. There was no evidence of a difference in immunogenicity (IFN-gamma and DTH conversion rates) but evidence of lower reactogenicity (scar size) with Danish-SSI 1331 compared to Glaxo-Evans 1077 vaccines.Entities:
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Year: 2006 PMID: 16723176 DOI: 10.1016/j.vaccine.2006.04.037
Source DB: PubMed Journal: Vaccine ISSN: 0264-410X Impact factor: 3.641