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Literature DB >> 16718813

Non-steroidal anti-inflammatory drugs in prevention of gastric cancer.

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) including cyclooxygenase 2 (COX-2) selective inhibitors, are potential agents for the chemoprevention of gastric cancer. Epidemiological and experimental studies have shown that NSAID use is associated with a reduced risk of gastric cancer although many questions remain unanswered such as the optimal dose and duration of treatment. The possible mechanisms for the suppressor effect of NSAIDs on carcinogenesis are the ability to induce apoptosis in epithelial cells and regulation of angiogenesis. Both COX-dependent and COX-independent pathways have a role in the biological activity of NSAIDs. Knowledge of how NSAIDs prevent neoplastic growth will greatly aid the design of better chemopreventive drugs and novel treatments for gastric cancer.

Entities: Disease Gene

Mesh：

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Year: 2006 PMID： 16718813 PMCID： PMC4087805 DOI： 10.3748/wjg.v12.i18.2884

Source DB: PubMed Journal: World J Gastroenterol ISSN： 1007-9327 Impact factor: 5.742

89 in total

1. Effects of nonsteroidal anti-inflammatory drugs on Helicobacter pylori-infected gastric mucosae of mice: apoptosis, cell proliferation, and inflammatory activity.

Authors: T I Kim; Y C Lee; K H Lee; J H Han; C Y Chon; Y M Moon; J K Kang; I S Park
Journal: Infect Immun Date: 2001-08 Impact factor: 3.441

2. MAPK (ERK2) kinase--a key target for NSAIDs-induced inhibition of gastric cancer cell proliferation and growth.

Authors: S S Husain; I L Szabo; R Pai; B Soreghan; M K Jones; A S Tarnawski
Journal: Life Sci Date: 2001-11-09 Impact factor: 5.037

Review 3. Review: molecular pathology of cyclooxygenase-2 in cancer-induced angiogenesis.

Authors: E Fosslien
Journal: Ann Clin Lab Sci Date: 2001-10 Impact factor: 1.256

Review 4. Cyclooxygenase-2 upregulation as a perigenetic change in carcinogenesis.

Authors: S Tsuji; M Tsujii; S Kawano; M Hori
Journal: J Exp Clin Cancer Res Date: 2001-03

5. Cyclooxygenase-2 expression during carcinogenesis in the human stomach.

Authors: Bastiaan P van Rees; Kirsi Saukkonen; Ari Ristimäki; Wojciech Polkowski; Guido N J Tytgat; Paul Drillenburg; G Johan A Offerhaus
Journal: J Pathol Date: 2002-02 Impact factor: 7.996

6. 12-Lipoxygenase inhibition induced apoptosis in human gastric cancer cells.

Authors: B C Wong; W P Wang; C H Cho; X M Fan; M C Lin; H F Kung; S K Lam
Journal: Carcinogenesis Date: 2001-09 Impact factor: 4.944

7. Non-steroidal anti-inflammatory drugs induce apoptosis in gastric cancer cells through up-regulation of bax and bak.

Authors: X M Zhou; B C Wong; X M Fan; H B Zhang; M C Lin; H F Kung; D M Fan; S K Lam
Journal: Carcinogenesis Date: 2001-09 Impact factor: 4.944

8. Involvement of cyclooxygenase-2 in hyperplastic gastritis induced by Helicobacter pylori infection in C57BL/6 mice.

Authors: F Xiao; T Furuta; M Takashima; N Shirai; H Hanai
Journal: Aliment Pharmacol Ther Date: 2001-06 Impact factor: 8.171

9. Growth inhibition and apoptosis induction of Sulindac on Human gastric cancer cells.

Authors: Y L Wu; B Sun; X J Zhang; S N Wang; H Y He; M M Qiao; J Zhong; J Y Xu
Journal: World J Gastroenterol Date: 2001-12 Impact factor: 5.742

Review 10. Chronic immune activation and inflammation as the cause of malignancy.

Authors: K J O'Byrne; A G Dalgleish
Journal: Br J Cancer Date: 2001-08-17 Impact factor: 7.640

14 in total

1. Fruit and vegetable consumption and risk of distal gastric cancer in the Shanghai Women's and Men's Health studies.

Authors: Meira Epplein; Xiao-Ou Shu; Yong-Bing Xiang; Wong-Ho Chow; Gong Yang; Hong-Lan Li; Bu-Tian Ji; Hui Cai; Yu-Tang Gao; Wei Zheng
Journal: Am J Epidemiol Date: 2010-07-20 Impact factor: 4.897

2. Potency of non-steroidal anti-inflammatory drugs in chemotherapy.

Authors: Lucia Hiľovská; Rastislav Jendželovský; Peter Fedoročko
Journal: Mol Clin Oncol Date: 2014-10-16

3. PTGS2 and IL6 genetic variation and risk of breast and prostate cancer: results from the Breast and Prostate Cancer Cohort Consortium (BPC3).

Authors: Laure Dossus; Rudolf Kaaks; Federico Canzian; Demetrius Albanes; Sonja I Berndt; Heiner Boeing; Julie Buring; Stephen J Chanock; Francoise Clavel-Chapelon; Heather Spencer Feigelson; John M Gaziano; Edward Giovannucci; Carlos Gonzalez; Christopher A Haiman; Göran Hallmans; Susan E Hankinson; Richard B Hayes; Brian E Henderson; Robert N Hoover; David J Hunter; Kay-Tee Khaw; Laurence N Kolonel; Peter Kraft; Jing Ma; Loic Le Marchand; Eiliv Lund; Petra H M Peeters; Meir Stampfer; Dan O Stram; Gilles Thomas; Michael J Thun; Anne Tjonneland; Dimitrios Trichopoulos; Rosario Tumino; Elio Riboli; Jarmo Virtamo; Stephanie J Weinstein; Meredith Yeager; Regina G Ziegler; David G Cox
Journal: Carcinogenesis Date: 2009-12-04 Impact factor: 4.944

4. Nonsteroidal antiinflammatory drugs and risk of gastric adenocarcinoma: the multiethnic cohort study.

Authors: Meira Epplein; Abraham M Y Nomura; Lynne R Wilkens; Brian E Henderson; Laurence N Kolonel
Journal: Am J Epidemiol Date: 2009-07-07 Impact factor: 4.897

Review 5. The risk of gastric cancer in patients with duodenal and gastric ulcer: research progresses and clinical implications.

Authors: Zunwu Zhang
Journal: J Gastrointest Cancer Date: 2007

6. Anti-Helicobacter pylori therapy followed by celecoxib on progression of gastric precancerous lesions.

Authors: Li-Jing Zhang; Shi-Yan Wang; Xiao-Hui Huo; Zhen-Long Zhu; Jian-Kun Chu; Jin-Cheng Ma; Dong-Sheng Cui; Ping Gu; Zeng-Ren Zhao; Ming-Wei Wang; Jun Yu
Journal: World J Gastroenterol Date: 2009-06-14 Impact factor: 5.742

Review 7. Etiology and Prevention of Gastric Cancer.

Authors: Xiao Jiao Cheng; Jia Cheng Lin; Shui Ping Tu
Journal: Gastrointest Tumors Date: 2016-02-12

Review 8. The association of Streptococcus bovis/gallolyticus with colorectal tumors: the nature and the underlying mechanisms of its etiological role.

Authors: Ahmed S Abdulamir; Rand R Hafidh; Fatimah Abu Bakar
Journal: J Exp Clin Cancer Res Date: 2011-01-20

9. Cyclooxygenase-2 overexpression in chronic inflammation associated with benign prostatic hyperplasia: is it related to apoptosis and angiogenesis of prostate cancer?

Authors: Byung Hoon Kim; Chun Il Kim; Hyuk Soo Chang; Mi Sun Choe; Hye Ra Jung; Duk Yoon Kim; Choal Hee Park
Journal: Korean J Urol Date: 2011-04-22

10. Prevention of posterior capsular opacification through cyclooxygenase-2 inhibition.

Authors: Heather L Chandler; Curtis A Barden; Ping Lu; Donna F Kusewitt; Carmen M H Colitz
Journal: Mol Vis Date: 2007-04-30 Impact factor: 2.367