OBJECTIVE: S-100B and NSE proteins are considered to be neurobiochemical markers for the brain damage. The aim of this study was to consider the diagnostic and prognostic validity of the initial serum levels of S-100B and NSE in clinical use. METHODS: Forty-five patients with traumatic brain injury were included in this prospective study. Neurologic examination and CCT-scan were performed. S-100B and NSE were analysed. Patients were divided in two groups depending on the severity of injury. RESULTS: The results showed a significant difference between the S-100B serum concentration and the two groups-minor head injuries and severe head injuries. A statistically significant correlation was observed between an increase of S-100B and NSE serum values and a cerebral pathological finding in CT scans. CONCLUSION: The clear correlation between S-100B and NSE serum concentrations and CCT findings does not validate both markers as an independent predictor of diagnosis and prognosis of brain injury.
OBJECTIVE:S-100B and NSE proteins are considered to be neurobiochemical markers for the brain damage. The aim of this study was to consider the diagnostic and prognostic validity of the initial serum levels of S-100B and NSE in clinical use. METHODS: Forty-five patients with traumatic brain injury were included in this prospective study. Neurologic examination and CCT-scan were performed. S-100B and NSE were analysed. Patients were divided in two groups depending on the severity of injury. RESULTS: The results showed a significant difference between the S-100B serum concentration and the two groups-minor head injuries and severe head injuries. A statistically significant correlation was observed between an increase of S-100B and NSE serum values and a cerebral pathological finding in CT scans. CONCLUSION: The clear correlation between S-100B and NSE serum concentrations and CCT findings does not validate both markers as an independent predictor of diagnosis and prognosis of brain injury.
Authors: Linda Papa; Lawrence M Lewis; Jay L Falk; Zhiqun Zhang; Salvatore Silvestri; Philip Giordano; Gretchen M Brophy; Jason A Demery; Neha K Dixit; Ian Ferguson; Ming Cheng Liu; Jixiang Mo; Linnet Akinyi; Kara Schmid; Stefania Mondello; Claudia S Robertson; Frank C Tortella; Ronald L Hayes; Kevin K W Wang Journal: Ann Emerg Med Date: 2011-11-08 Impact factor: 5.721
Authors: Cyrus Safinia; Eric M Bershad; H Brent Clark; Karen SantaCruz; Naila Alakbarova; Jose I Suarez; Afshin A Divani Journal: J Vasc Interv Neurol Date: 2016-10
Authors: Matt Aldag; Regina C Armstrong; Faris Bandak; Patrick S F Bellgowan; Timothy Bentley; Sean Biggerstaff; Katrina Caravelli; Joan Cmarik; Alicia Crowder; Thomas J DeGraba; Travis A Dittmer; Richard G Ellenbogen; Colin Greene; Raj K Gupta; Ramona Hicks; Stuart Hoffman; Robert C Latta; Michael J Leggieri; Donald Marion; Robert Mazzoli; Michael McCrea; John O'Donnell; Mark Packer; James B Petro; Todd E Rasmussen; Wendy Sammons-Jackson; Richard Shoge; Victoria Tepe; Ladd A Tremaine; James Zheng Journal: J Neurotrauma Date: 2017-09 Impact factor: 5.269
Authors: Linda Papa; Claudia S Robertson; Kevin K W Wang; Gretchen M Brophy; H Julia Hannay; Shelley Heaton; Ilona Schmalfuss; Andrea Gabrielli; Ronald L Hayes; Steven A Robicsek Journal: Neurocrit Care Date: 2015-02 Impact factor: 3.210