OBJECTIVE: To develop a method to determine the distribution of articular cartilage in the hip and to evaluate the potential of the method in a study of normal weight-bearing effects in asymptomatic young volunteers. DESIGN: Six volunteers were scanned after periods of standing and lying supine, using 3D gradient-echo magnetic resonance imaging (MRI). The protocol was repeated for two successive weeks to determine reproducibility. The femoral and acetabular cartilage layers were segmented as a single unit and thickness distribution maps were calculated using a spherical bone model as a frame of reference. Thickness maps were combined over the population using the bone model and post-weight-bearing and post-resting maps were compared. RESULTS: Mean thickness values were compared using an analysis of variance and a significant increase in cartilage thickness of 0.05 mm (P=0.02) was observed. The reproducibility of the method, assessed using test-retest coefficient of variation was 2.5%. CONCLUSIONS: The technique is reproducible, sensitive to sub-millimetre changes in thickness and may be useful in monitoring changes due to disease progression in patients with arthritis of the hip.
OBJECTIVE: To develop a method to determine the distribution of articular cartilage in the hip and to evaluate the potential of the method in a study of normal weight-bearing effects in asymptomatic young volunteers. DESIGN: Six volunteers were scanned after periods of standing and lying supine, using 3D gradient-echo magnetic resonance imaging (MRI). The protocol was repeated for two successive weeks to determine reproducibility. The femoral and acetabular cartilage layers were segmented as a single unit and thickness distribution maps were calculated using a spherical bone model as a frame of reference. Thickness maps were combined over the population using the bone model and post-weight-bearing and post-resting maps were compared. RESULTS: Mean thickness values were compared using an analysis of variance and a significant increase in cartilage thickness of 0.05 mm (P=0.02) was observed. The reproducibility of the method, assessed using test-retest coefficient of variation was 2.5%. CONCLUSIONS: The technique is reproducible, sensitive to sub-millimetre changes in thickness and may be useful in monitoring changes due to disease progression in patients with arthritis of the hip.
Authors: A Hosseini; S K Van de Velde; M Kozanek; T J Gill; A J Grodzinsky; H E Rubash; G Li Journal: Osteoarthritis Cartilage Date: 2010-04-29 Impact factor: 6.576
Authors: Julio Carballido-Gamio; Jenny Folkesson; Dimitrios C Karampinos; Thomas Baum; Thomas M Link; Sharmila Majumdar; Roland Krug Journal: Magn Reson Med Date: 2011-03-22 Impact factor: 4.668
Authors: Simon Damian Steppacher; Malin Kristin Meier; Christoph Emanuel Albers; Moritz Tannast; Klaus Arno Siebenrock Journal: Cartilage Date: 2021-02-08 Impact factor: 3.117