Literature DB >> 16707526

Injectable self inflating hydrogel pellet expanders for the treatment of orbital volume deficiency in congenital microphthalmos: preliminary results with a new therapeutic approach.

M P Schittkowski1, R F Guthoff.   

Abstract

BACKGROUND/AIM: Children with congenital microphthalmos are usually able to wear an eye prosthesis but the cosmetic aspect is determined by the size of the orbital volume deficiency. Instead of using a ball shaped standard hydrogel expander or a regular orbital implant, which would necessitate enucleation of the microphthalmic eye, this study investigates the feasibility of volume augmentation with injectable pellet expanders, as formerly suggested for acquired anophthalmos in adults only.
METHOD: The pellet expander is made from a self inflating hydrogel that takes up water by osmosis (dry state: length 8 mm, diameter 2 mm, volume 0.025 ml; in vitro hydrated state after around 1 day: length 15 mm, diameter 4 mm, volume 0.24 ml; swelling capacity: 9.6-fold). This report concerns six patients (two girls and four boys) aged between 4 months and 42 months with unilateral microphthalmos who were treated by injection of 4-14 pellet expanders into the retrobulbar orbital tissue. Volume augmentation was 1-3.5 ml. The pellets were injected using a customised trocar and placed behind the microphthalmos directed into the intraconal space.
RESULTS: The increasing orbital volume was noticeable within 2 days and was confirmed by ultrasonography and magnetic resonance imaging. The final result can be anticipated by the volume augmentation effect produced by the amount of saline solution injected in the orbital apex region. All patients were fitted with an artificial eye, which was subsequently enlarged every 3-5 months. Anophthalmic enophthalmos was fully compensated with this technique. No complications have been encountered to date.
CONCLUSIONS: Orbital volume augmentation with injectable self inflating hydrogel expander pellets is apparently a safe, quick, and minimally invasive technique for various indications in orbital reconstructive surgery-for example, to treat an enophthalmic appearance in microphthalmos and congenital or acquired anophthalmos.

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Year:  2006        PMID: 16707526      PMCID: PMC1857413          DOI: 10.1136/bjo.2006.092478

Source DB:  PubMed          Journal:  Br J Ophthalmol        ISSN: 0007-1161            Impact factor:   4.638


  18 in total

1.  Hydrophilic expanders for the congenital anophthalmic socket.

Authors:  R Downes; M Lavin; R Collin
Journal:  Adv Ophthalmic Plast Reconstr Surg       Date:  1992

2.  Changes in orbital dimensions following enucleation.

Authors:  L Apt; S Isenberg
Journal:  Arch Ophthalmol       Date:  1973-11

3.  Expansion of the socket and orbit for congenital clinical anophthalmia.

Authors:  Karsten Kurt Helmuth Gundlach; Rudolf Friedrich Guthoff; Volker Hermann Martin Hingst; Michael Peter Schittkowski; Ulrich Christian Bier
Journal:  Plast Reconstr Surg       Date:  2005-10       Impact factor: 4.730

4.  Management of the contracted socket.

Authors:  J R Collin; P A Moriarty
Journal:  Trans Ophthalmol Soc U K       Date:  1982-04

5.  Surgical management of the anophthalmic orbit, part 1: congenital.

Authors:  D Krastinova; M B Kelly; M Mihaylova
Journal:  Plast Reconstr Surg       Date:  2001-09-15       Impact factor: 4.730

6.  Congenital microphthalmos with orbital cysts: distinct diagnostic features and management.

Authors:  Imtiaz A Chaudhry; Yonca O Arat; Farrukh A Shamsi; Milton Boniuk
Journal:  Ophthalmic Plast Reconstr Surg       Date:  2004-11       Impact factor: 1.746

Review 7.  Congenital and acquired anophthalmia.

Authors:  L F Handler; K L Heher; J A Katowitz
Journal:  Curr Opin Ophthalmol       Date:  1994-10       Impact factor: 3.761

Review 8.  Use of self-expanding, hydrophilic osmotic expanders (hydrogel) in the reconstruction of congenital clinical anophthalmos.

Authors:  Robert A Mazzoli; William R Raymond; Darryl J Ainbinder; Elizabeth A Hansen
Journal:  Curr Opin Ophthalmol       Date:  2004-10       Impact factor: 3.761

9.  The effect of early enucleation on the orbit in animals and humans.

Authors:  R E Kennedy
Journal:  Adv Ophthalmic Plast Reconstr Surg       Date:  1992

Review 10.  The ocularists' management of congenital microphthalmos and anophthalmos.

Authors:  G L Dootz
Journal:  Adv Ophthalmic Plast Reconstr Surg       Date:  1992
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  10 in total

1.  [Volume overload from hydrogel expander after treatment for enophthalmos].

Authors:  M Küstner; P Riebeling; F Podmelle; W Kaduk; F Tost
Journal:  Ophthalmologe       Date:  2009-12       Impact factor: 1.059

2.  [Therapy options for blind microphthalmos and clinical anophthalmos].

Authors:  M P Schittkowski
Journal:  Ophthalmologe       Date:  2012-11       Impact factor: 1.059

3.  Injectable self inflating hydrogel pellet expanders for the treatment of orbital volume deficiency in congenital microphthalmos: preliminary results with a new therapeutic approach.

Authors:  M P Schittkowski; R F Guthoff
Journal:  Br J Ophthalmol       Date:  2006-05-17       Impact factor: 4.638

4.  Congenital anophthalmia: a review of dealing with volume.

Authors:  C Robert Bernardino
Journal:  Middle East Afr J Ophthalmol       Date:  2010-04

5.  Results of lacrimal assessment in patients with congenital clinical anophthalmos or blind microphthalmos.

Authors:  M P Schittkowski; R F Guthoff
Journal:  Br J Ophthalmol       Date:  2007-06-13       Impact factor: 4.638

6.  Long-term outcomes after cosmetic customized prostheses and dermis fat graft in congenital anophthalmia: a retrospective multicentre study.

Authors:  Alessandra Claudia Modugno; Antonio Giordano Resti; Giacomilde Mazzone; Caterina Moretti; Maria Rosa Terreni; Giorgio Albanese; Gustavo Savino; Gabriela Grimaldi; Richard Collin
Journal:  Eye (Lond)       Date:  2018-07-24       Impact factor: 3.775

Review 7.  Rare Diseases of the Orbit.

Authors:  Ulrich Kisser; Jens Heichel; Alexander Glien
Journal:  Laryngorhinootologie       Date:  2021-04-30       Impact factor: 1.057

8.  Congenital anophthalmia and microphthalmia: epidemiology and orbitofacial rehabilitation.

Authors:  Sara Llorente-González; J Peralta-Calvo; J M Abelairas-Gómez
Journal:  Clin Ophthalmol       Date:  2011-12-13

9.  Management of Congenital Clinical Anophthalmos with Orbital Cyst: A Kinshasa Case Report.

Authors:  Thomas Stahnke; Andreas Erbersdobler; Steffi Knappe; Rudolf F Guthoff; Ngoy J Kilangalanga
Journal:  Case Rep Ophthalmol Med       Date:  2018-10-09

10.  Anophthalmia and serious microphthalmia: a summary of the problems associated with antenatal diagnosis and therapeutic refunding in Sub-Saharan Africa.

Authors:  Ibrahim Abib Diomande; Abdoulaye Toure; Konan Virgile Koffi; Gossé François Diomande; Windinmanégdé Pierre Djiguimde; Nouraly Habib; Ahgbatouhabéba Ahnoux-Zabsonre
Journal:  Int Med Case Rep J       Date:  2015-11-04
  10 in total

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