Literature DB >> 1670689

Presymptomatic screening for multiple endocrine neoplasia type 2A with linked DNA markers. The MEN 2A International Collaborative Group.

C G Mathew1, D F Easton, Y Nakamura, B A Ponder.   

Abstract

Seven DNA markers from the pericentromeric region of chromosome 10 were tested for linkage to MEN 2A in a panel of 17 families. Four of the markers proved to be tightly linked and therefore suitable for predictive testing. The markers were used to estimate carrier risks for individuals who had a negative biochemical screening test for thyroid C-cell hyperplasia. The analysis substantially altered the carrier risks of most of these individuals, which suggests that typing with DNA markers should be introduced into the screening programme of MEN 2A families. Accurate prenatal diagnosis for this disorder is also now possible.

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Year:  1991        PMID： 1670689     DOI： 10.1016/0140-6736(91)93329-8

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  13 in total

1.  Construction of radiation-reduced hybrids and their use in mapping of microclones from chromosome 10p11.2-q11.2.

Authors:  S Fujita; E Shin; T Nakamura; H Kurahashi; Y Kaneda; K Tanaka; T Mori; S Takai; I Nishisho
Journal:  Jpn J Hum Genet       Date:  1993-12

2.  A multiple interval physical map of the pericentromeric region of human chromosome 10.

Authors:  A Tunnacliffe; M S Jackson; E Gardner; D R Love; J K Moore; S E Mole; L M Mulligan; A Graham; G Finocchiaro; S Orstavik
Journal:  Hum Genet       Date:  1994-03       Impact factor: 4.132

3.  Genetic analysis of 24 French families with multiple endocrine neoplasia type 2A.

Authors:  S A Narod; M F Lavoué; K Morgan; C Calmettes; H Sobol; P J Goodfellow; G M Lenoir
Journal:  Am J Hum Genet       Date:  1992-09       Impact factor: 11.025

4.  The clinical implications of a positive calcitonin test for C-cell hyperplasia in genetically unaffected members of an MEN2A kindred.

Authors:  R M Landsvater; A G Rombouts; G J te Meerman; J M Schillhorn-van Veen; M J Berends; R A Geerdink; A Struyvenberg; C H Buys; C J Lips
Journal:  Am J Hum Genet       Date:  1993-02       Impact factor: 11.025

5.  A new polymorphic marker (D10S97) tightly linked to the multiple endocrine neoplasia type 2A (MEN2A) locus.

Authors:  J B Lichter; J Wu; A R Brooks-Wilson; M Difillipantonio; S Brewster; D C Ward; P J Goodfellow; K K Kidd
Journal:  Hum Genet       Date:  1993-01       Impact factor: 4.132

6.  A 1.5-megabase yeast artificial chromosome contig from human chromosome 10q11.2 connecting three genetic loci (RET, D10S94, and D10S102) closely linked to the MEN2A locus.

Authors:  T C Lairmore; S Dou; J R Howe; D Chi; K Carlson; R Veile; S K Mishra; S A Wells; H Donis-Keller
Journal:  Proc Natl Acad Sci U S A       Date:  1993-01-15       Impact factor: 11.205

7.  Presymptomatic screening for medullary thyroid carcinoma in patients with multiple endocrine neoplasia type 2A.

Authors:  A Frilling; H D Röher; B A Ponder
Journal:  World J Surg       Date:  1994 Jul-Aug       Impact factor: 3.352

8.  Fine-scale mapping of the gene responsible for multiple endocrine neoplasia type 1 (MEN 1).

Authors:  M Fujimori; S A Wells; Y Nakamura
Journal:  Am J Hum Genet       Date:  1992-02       Impact factor: 11.025

9.  Molecular Screening for RET Proto-Oncogene Mutations in a German MEN2A Pedigree.

Authors:  Iris Wundrack; Jeannette Reichert; Heinz-Joachim Langer; Ernst Leicht; Marukke Herrmann; Frank Subke; Eckart Meese; Nikolaus Blin
Journal:  Endocr Pathol       Date:  1996       Impact factor: 3.943

10.  Predictive DNA testing and prophylactic thyroidectomy in patients at risk for multiple endocrine neoplasia type 2A.

Authors:  S A Wells; D D Chi; K Toshima; L P Dehner; C M Coffin; S B Dowton; J L Ivanovich; M K DeBenedetti; W G Dilley; J F Moley
Journal:  Ann Surg       Date:  1994-09       Impact factor: 12.969
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