OBJECTIVE: To identify any chromosomal region that shows evidence for linkage to age-related hearing loss in humans. DESIGN: Evaluation of genetic linkage using sibling-pair methods for hearing loss collected via self-report questionnaire and markers from a genome screening collected from a population-based representative sample of male fraternal twins born from 1917 to 1927. SUBJECTS: Members of a group of 6108 World War II and Korean War veteran twins (2059 complete pairs) who completed a health history questionnaire at a mean age of 74.3 years (range, 69-82 years). A subset of 711 twins (343 complete pairs) later provided a blood sample for DNA extraction in a study of genetic factors in healthy aging. Among the complete pairs were approximately 160 fraternal twins; 50 of these pairs were concordant for age-related hearing loss with at least 1 co-twin reporting bilateral hearing loss and with marker data available for analysis. RESULTS: A region suggestive of linkage was found on chromosome 3q, with a logarithm of the odds score of 2.5 in the same region of this chromosome where the DFNA18 locus resides, which has been reported to cause a form of progressive hereditary hearing loss. CONCLUSIONS: To our knowledge, this is the first sample from the general population that has been used in a genome screening for qualitative hearing loss. The results, if confirmed, suggest that genetic variation in the region of DFNA18 may be responsible for hearing loss with age in the general population.
OBJECTIVE: To identify any chromosomal region that shows evidence for linkage to age-related hearing loss in humans. DESIGN: Evaluation of genetic linkage using sibling-pair methods for hearing loss collected via self-report questionnaire and markers from a genome screening collected from a population-based representative sample of male fraternal twins born from 1917 to 1927. SUBJECTS: Members of a group of 6108 World War II and Korean War veteran twins (2059 complete pairs) who completed a health history questionnaire at a mean age of 74.3 years (range, 69-82 years). A subset of 711 twins (343 complete pairs) later provided a blood sample for DNA extraction in a study of genetic factors in healthy aging. Among the complete pairs were approximately 160 fraternal twins; 50 of these pairs were concordant for age-related hearing loss with at least 1 co-twin reporting bilateral hearing loss and with marker data available for analysis. RESULTS: A region suggestive of linkage was found on chromosome 3q, with a logarithm of the odds score of 2.5 in the same region of this chromosome where the DFNA18 locus resides, which has been reported to cause a form of progressive hereditary hearing loss. CONCLUSIONS: To our knowledge, this is the first sample from the general population that has been used in a genome screening for qualitative hearing loss. The results, if confirmed, suggest that genetic variation in the region of DFNA18 may be responsible for hearing loss with age in the general population.
Authors: Kelly L Kane; Chantal M Longo-Guess; Leona H Gagnon; Dalian Ding; Richard J Salvi; Kenneth R Johnson Journal: Hear Res Date: 2011-11-22 Impact factor: 3.208
Authors: Jeroen R Huyghe; Lut Van Laer; Jan-Jaap Hendrickx; Erik Fransen; Kelly Demeester; Vedat Topsakal; Sylvia Kunst; Minna Manninen; Mona Jensen; Amanda Bonaconsa; Manuela Mazzoli; Manuela Baur; Samuli Hannula; Elina Mäki-Torkko; Angeles Espeso; Els Van Eyken; Antonia Flaquer; Christian Becker; Dafydd Stephens; Martti Sorri; Eva Orzan; Michael Bille; Agnete Parving; Ilmari Pyykkö; Cor W R J Cremers; Hannie Kremer; Paul H Van de Heyning; Thomas F Wienker; Peter Nürnberg; Markus Pfister; Guy Van Camp Journal: Am J Hum Genet Date: 2008-08-28 Impact factor: 11.025
Authors: Dina L Newman; Laurel M Fisher; Jeffrey Ohmen; Robert Parody; Chin-To Fong; Susan T Frisina; Frances Mapes; David A Eddins; D Robert Frisina; Robert D Frisina; Rick A Friedman Journal: Hear Res Date: 2012-10-25 Impact factor: 3.208
Authors: Lut Van Laer; Jeroen R Huyghe; Samuli Hannula; Els Van Eyken; Dietrich A Stephan; Elina Mäki-Torkko; Pekka Aikio; Erik Fransen; Alana Lysholm-Bernacchi; Martti Sorri; Matthew J Huentelman; Guy Van Camp Journal: Eur J Hum Genet Date: 2010-01-13 Impact factor: 4.246
Authors: E Van Eyken; G Van Camp; E Fransen; V Topsakal; J J Hendrickx; K Demeester; P Van de Heyning; E Mäki-Torkko; S Hannula; M Sorri; M Jensen; A Parving; M Bille; M Baur; M Pfister; A Bonaconsa; M Mazzoli; E Orzan; A Espeso; D Stephens; K Verbruggen; J Huyghe; I Dhooge; P Huygen; H Kremer; C W R J Cremers; S Kunst; M Manninen; I Pyykkö; A Lacava; M Steffens; T F Wienker; L Van Laer Journal: J Med Genet Date: 2007-05-18 Impact factor: 6.318
Authors: Erik Fransen; Vedat Topsakal; Jan-Jaap Hendrickx; Lut Van Laer; Jeroen R Huyghe; Els Van Eyken; Nele Lemkens; Samuli Hannula; Elina Mäki-Torkko; Mona Jensen; Kelly Demeester; Anke Tropitzsch; Amanda Bonaconsa; Manuela Mazzoli; Angeles Espeso; Katia Verbruggen; Joke Huyghe; Patrick L M Huygen; Sylvia Kunst; Minna Manninen; Amalia Diaz-Lacava; Michael Steffens; Thomas F Wienker; Ilmari Pyykkö; Cor W R J Cremers; Hannie Kremer; Ingeborg Dhooge; Dafydd Stephens; Eva Orzan; Markus Pfister; Michael Bille; Agnete Parving; Martti Sorri; Paul Van de Heyning; Guy Van Camp Journal: J Assoc Res Otolaryngol Date: 2008-06-10