Literature DB >> 16702418

Loss-of-function alleles of the JIL-1 kinase are strong suppressors of position effect variegation of the wm4 allele in Drosophila.

Stephanie Lerach1, Weiguo Zhang, Xiaomin Bao, Huai Deng, Jack Girton, Jørgen Johansen, Kristen M Johansen.   

Abstract

In this article we show that hypomorphic loss-of-function alleles of the JIL-1 histone H3S10 kinase are strong suppressors of position effect variegation (PEV) of the wm4 allele and that lack of JIL-1 activity can counteract the effect of the dominant enhancer Evar2-1 on PEV.

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Year:  2006        PMID： 16702418      PMCID： PMC1569694          DOI： 10.1534/genetics.106.059253

Source DB:  PubMed          Journal:  Genetics        ISSN： 0016-6731            Impact factor:   4.562


  14 in total

Review 1.  Heterochromatin function in complex genomes.

Authors:  S Henikoff
Journal:  Biochim Biophys Acta       Date:  2000-02-14

Review 2.  Heterochromatin: new possibilities for the inheritance of structure.

Authors:  Shiv I S Grewal; Sarah C R Elgin
Journal:  Curr Opin Genet Dev       Date:  2002-04       Impact factor: 5.578

3.  Increased expression of Drosophila Su(var)3-7 triggers Su(var)3-9-dependent heterochromatin formation.

Authors:  Marion Delattre; Anne Spierer; Yannis Jaquet; Pierre Spierer
Journal:  J Cell Sci       Date:  2004-12-01       Impact factor: 5.285

4.  Variegation in Drosophila and the Inert Chromosome Regions.

Authors:  J Schultz
Journal:  Proc Natl Acad Sci U S A       Date:  1936-01       Impact factor: 11.205

Review 5.  Unfolding the mysteries of heterochromatin.

Authors:  L L Wallrath
Journal:  Curr Opin Genet Dev       Date:  1998-04       Impact factor: 5.578

6.  The JIL-1 kinase regulates the structure of Drosophila polytene chromosomes.

Authors:  Huai Deng; Weiguo Zhang; Xiaomin Bao; Janine N Martin; Jack Girton; Jørgen Johansen; Kristen M Johansen
Journal:  Chromosoma       Date:  2005-06-29       Impact factor: 4.316

7.  Su(var) genes regulate the balance between euchromatin and heterochromatin in Drosophila.

Authors:  Anja Ebert; Gunnar Schotta; Sandro Lein; Stefan Kubicek; Veiko Krauss; Thomas Jenuwein; Gunter Reuter
Journal:  Genes Dev       Date:  2004-12-01       Impact factor: 11.361

8.  Genetic and phenotypic analysis of alleles of the Drosophila chromosomal JIL-1 kinase reveals a functional requirement at multiple developmental stages.

Authors:  Weiguo Zhang; Ye Jin; Yun Ji; Jack Girton; Jørgen Johansen; Kristen M Johansen
Journal:  Genetics       Date:  2003-11       Impact factor: 4.562

Review 9.  Heterochromatin and gene expression in Drosophila.

Authors:  K S Weiler; B T Wakimoto
Journal:  Annu Rev Genet       Date:  1995       Impact factor: 16.830

10.  JIL-1, a chromosomal kinase implicated in regulation of chromatin structure, associates with the male specific lethal (MSL) dosage compensation complex.

Authors:  Y Jin; Y Wang; J Johansen; K M Johansen
Journal:  J Cell Biol       Date:  2000-05-29       Impact factor: 10.539
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  19 in total

1.  JIL-1 and Su(var)3-7 interact genetically and counteract each other's effect on position-effect variegation in Drosophila.

Authors:  Huai Deng; Weili Cai; Chao Wang; Stephanie Lerach; Marion Delattre; Jack Girton; Jørgen Johansen; Kristen M Johansen
Journal:  Genetics       Date:  2010-05-10       Impact factor: 4.562

2.  A balance between euchromatic (JIL-1) and heterochromatic [SU(var)2-5 and SU(var)3-9] factors regulates position-effect variegation in Drosophila.

Authors:  Chao Wang; Jack Girton; Jørgen Johansen; Kristen M Johansen
Journal:  Genetics       Date:  2011-04-21       Impact factor: 4.562

Review 3.  Regulation of chromatin structure by histone H3S10 phosphorylation.

Authors:  Kristen M Johansen; Jørgen Johansen
Journal:  Chromosome Res       Date:  2006       Impact factor: 5.239

4.  H2Av facilitates H3S10 phosphorylation but is not required for heat shock-induced chromatin decondensation or transcriptional elongation.

Authors:  Yeran Li; Chao Wang; Weili Cai; Saheli Sengupta; Michael Zavortink; Huai Deng; Jack Girton; Jørgen Johansen; Kristen M Johansen
Journal:  Development       Date:  2017-08-14       Impact factor: 6.868

Review 5.  Molecular targets of epigenetic regulation and effectors of environmental influences.

Authors:  Supratim Choudhuri; Yue Cui; Curtis D Klaassen
Journal:  Toxicol Appl Pharmacol       Date:  2010-04-08       Impact factor: 4.219

6.  The epigenetic H3S10 phosphorylation mark is required for counteracting heterochromatic spreading and gene silencing in Drosophila melanogaster.

Authors:  Chao Wang; Weili Cai; Yeran Li; Huai Deng; Xiaomin Bao; Jack Girton; Jørgen Johansen; Kristen M Johansen
Journal:  J Cell Sci       Date:  2011-12-15       Impact factor: 5.285

7.  Variation in Position Effect Variegation Within a Natural Population.

Authors:  Keegan J P Kelsey; Andrew G Clark
Journal:  Genetics       Date:  2017-09-20       Impact factor: 4.562

8.  RNA polymerase II-mediated transcription at active loci does not require histone H3S10 phosphorylation in Drosophila.

Authors:  Weili Cai; Xiaomin Bao; Huai Deng; Ye Jin; Jack Girton; Jørgen Johansen; Kristen M Johansen
Journal:  Development       Date:  2008-07-30       Impact factor: 6.868

9.  Phosphorylation of SU(VAR)3-9 by the chromosomal kinase JIL-1.

Authors:  Joern Boeke; Catherine Regnard; Weili Cai; Jørgen Johansen; Kristen M Johansen; Peter B Becker; Axel Imhof
Journal:  PLoS One       Date:  2010-04-06       Impact factor: 3.240

10.  Reduced levels of Su(var)3-9 but not Su(var)2-5 (HP1) counteract the effects on chromatin structure and viability in loss-of-function mutants of the JIL-1 histone H3S10 kinase.

Authors:  Huai Deng; Xiaomin Bao; Weiguo Zhang; Jack Girton; Jørgen Johansen; Kristen M Johansen
Journal:  Genetics       Date:  2007-07-29       Impact factor: 4.562
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