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Literature DB >> 16699047

Transspecies transmission of the endogenous koala retrovirus.

Uwe Fiebig¹, Manuel Garcia Hartmann, Norbert Bannert, Reinhard Kurth, Joachim Denner.

Abstract

The koala retrovirus (KoRV) is a gammaretrovirus closely related to the gibbon ape leukemia virus and induces leukemias and immune deficiencies associated with opportunistic infections, such as chlamydiosis. Here we characterize a KoRV newly isolated from an animal in a German zoo and show infection of human and rat cell lines in vitro and of rats in vivo, using immunological and PCR methods for virus detection. The KoRV transmembrane envelope protein (p15E) was cloned and expressed, and p15E-specific neutralizing antibodies able to prevent virus infection in vitro were developed. Finally, evidence for immunosuppressive properties of the KoRV was obtained.

Entities: Disease Species

Mesh：

Year: 2006 PMID： 16699047 PMCID： PMC1472152 DOI： 10.1128/JVI.02597-05

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

25 in total

1. How does HIV induce AIDS? The virus protein hypothesis.

Authors: J Denner
Journal: J Hum Virol Date: 2000 Mar-Apr

2. Molecular identification and antibody testing of Chlamydophila pneumoniae in a subgroup of patients with HIV-associated dementia complex. Preliminary results.

Authors: Carlo Contini; Enrico Fainardi; Silva Seraceni; Enrico Granieri; Massimiliano Castellazzi; Rosario Cultrera
Journal: J Neuroimmunol Date: 2003-03 Impact factor: 3.478

3. Sensitive and specific immunological detection methods for porcine endogenous retroviruses applicable to experimental and clinical xenotransplantation.

Authors: S J Tacke; K Bodusch; A Berg; J Denner
Journal: Xenotransplantation Date: 2001-05 Impact factor: 3.907

4. Productive infection of human primary cells and cell lines with porcine endogenous retroviruses.

Authors: V Specke; S Rubant; J Denner
Journal: Virology Date: 2001-07-05 Impact factor: 3.616

5. Porcine endogenous retroviruses inhibit human immune cell function: risk for xenotransplantation?

Authors: S J Tacke; R Kurth; J Denner
Journal: Virology Date: 2000-03-01 Impact factor: 3.616

6. In vitro characterization of a koala retrovirus.

Authors: Nidia M Oliveira; Karen B Farrell; Maribeth V Eiden
Journal: J Virol Date: 2006-03 Impact factor: 5.103

7. Porcine endogenous retroviruses: in vitro host range and attempts to establish small animal models.

Authors: Volker Specke; Stefan J Tacke; Klaus Boller; Jochen Schwendemann; Joachim Denner
Journal: J Gen Virol Date: 2001-04 Impact factor: 3.891

8. Neutralizing antibodies against conserved domains of p15E of porcine endogenous retroviruses: basis for a vaccine for xenotransplantation?

Authors: Uwe Fiebig; Oliver Stephan; Reinhard Kurth; Joachim Denner
Journal: Virology Date: 2003-03-15 Impact factor: 3.616

9. Identification of receptors for pig endogenous retrovirus.

Authors: Thomas A Ericsson; Yasuhiro Takeuchi; Christian Templin; Gary Quinn; Shelli F Farhadian; James C Wood; Beth A Oldmixon; Kristen M Suling; Jennifer K Ishii; Yoshinori Kitagawa; Takayuki Miyazawa; Daniel R Salomon; Robin A Weiss; Clive Patience
Journal: Proc Natl Acad Sci U S A Date: 2003-05-09 Impact factor: 11.205

10. Isolation from the asian mouse Mus caroli of an endogenous type C virus related to infectious primate type C viruses.

Authors: M M Lieber; C J Sherr; G J Todaro; R E Benveniste; R Callahan; H G Coon
Journal: Proc Natl Acad Sci U S A Date: 1975-06 Impact factor: 11.205

51 in total

Review 9. Immunising with the transmembrane envelope proteins of different retroviruses including HIV-1: a comparative study.

Authors: Joachim Denner
Journal: Hum Vaccin Immunother Date: 2012-12-18 Impact factor: 3.452

10. Detection of a gammaretrovirus, XMRV, in the human population: open questions and implications for xenotransplantation.

Authors: Joachim Denner
Journal: Retrovirology Date: 2010-03-10 Impact factor: 4.602

Transspecies transmission of the endogenous koala retrovirus.

1. How does HIV induce AIDS? The virus protein hypothesis.

2. Molecular identification and antibody testing of Chlamydophila pneumoniae in a subgroup of patients with HIV-associated dementia complex. Preliminary results.

3. Sensitive and specific immunological detection methods for porcine endogenous retroviruses applicable to experimental and clinical xenotransplantation.

4. Productive infection of human primary cells and cell lines with porcine endogenous retroviruses.

5. Porcine endogenous retroviruses inhibit human immune cell function: risk for xenotransplantation?

6. In vitro characterization of a koala retrovirus.

7. Porcine endogenous retroviruses: in vitro host range and attempts to establish small animal models.

8. Neutralizing antibodies against conserved domains of p15E of porcine endogenous retroviruses: basis for a vaccine for xenotransplantation?

9. Identification of receptors for pig endogenous retrovirus.

10. Isolation from the asian mouse Mus caroli of an endogenous type C virus related to infectious primate type C viruses.

1. Changes in viral protein function that accompany retroviral endogenization.

2. Immunization with hybrid proteins containing the membrane proximal external region of HIV-1.

3. Broad-scale phylogenomics provides insights into retrovirus-host evolution.

4. Proliferation of endogenous retroviruses in the early stages of a host germ line invasion.

5. Tracking the Fate of Endogenous Retrovirus Segregation in Wild and Domestic Cats.

6. Phylogenetic Diversity of Koala Retrovirus within a Wild Koala Population.

7. Endogenous retroviruses--aiding and abetting genomic plasticity.

8. Construction and characterization of an infectious molecular clone of Koala retrovirus.

Review 9. Immunising with the transmembrane envelope proteins of different retroviruses including HIV-1: a comparative study.

10. Detection of a gammaretrovirus, XMRV, in the human population: open questions and implications for xenotransplantation.