Literature DB >> 10850893

How does HIV induce AIDS? The virus protein hypothesis.

J Denner1.   

Abstract

The genome, the structural and regulatory proteins of HIV-1, as well as the clinical course of the disease it induces are well studied. Despite this knowledge, it is still unknown how the virus induces AIDS. The disease is characterized by opportunistic infections based on a generalized and nonspecific immunosuppression. I present evidence indicating that the immunosuppressive domain of gp41 of HIV may be causually involved in the induction and progression of AIDS.

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Year:  2000        PMID： 10850893

Source DB:  PubMed          Journal:  J Hum Virol        ISSN： 1090-9508


  7 in total

Review 1.  Human endogenous retrovirus-K (HML-2): a comprehensive review.

Authors:  Marta Garcia-Montojo; Tara Doucet-O'Hare; Lisa Henderson; Avindra Nath
Journal:  Crit Rev Microbiol       Date:  2018-10-14       Impact factor: 7.624

2.  Transspecies transmission of the endogenous koala retrovirus.

Authors:  Uwe Fiebig; Manuel Garcia Hartmann; Norbert Bannert; Reinhard Kurth; Joachim Denner
Journal:  J Virol       Date:  2006-06       Impact factor: 5.103

Review 3.  Infection barriers to successful xenotransplantation focusing on porcine endogenous retroviruses.

Authors:  Joachim Denner; Ralf R Tönjes
Journal:  Clin Microbiol Rev       Date:  2012-04       Impact factor: 26.132

Review 4.  Immunising with the transmembrane envelope proteins of different retroviruses including HIV-1: a comparative study.

Authors:  Joachim Denner
Journal:  Hum Vaccin Immunother       Date:  2012-12-18       Impact factor: 3.452

5.  Modulation of cytokine release and gene expression by the immunosuppressive domain of gp41 of HIV-1.

Authors:  Joachim Denner; Magdalena Eschricht; Michael Lauck; Marwan Semaan; Philipp Schlaermann; Hyunmi Ryu; Levent Akyüz
Journal:  PLoS One       Date:  2013-01-30       Impact factor: 3.240

6.  Single mutations in the transmembrane envelope protein abrogate the immunosuppressive property of HIV-1.

Authors:  Vladimir A Morozov; Alexey V Morozov; Marwan Semaan; Joachim Denner
Journal:  Retrovirology       Date:  2012-08-13       Impact factor: 4.602

7.  Genetic characterization of feline leukemia virus from Florida panthers.

Authors:  Meredith A Brown; Mark W Cunningham; Alfred L Roca; Jennifer L Troyer; Warren E Johnson; Stephen J O'Brien
Journal:  Emerg Infect Dis       Date:  2008-02       Impact factor: 6.883
  7 in total

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