| Literature DB >> 16697052 |
Angelica Becaria1, Debomoy K Lahiri, Stephen C Bondy, DeMao Chen, Ali Hamadeh, Huihui Li, Russell Taylor, Arezoo Campbell.
Abstract
Inflammatory and oxidative events are up-regulated in the brain of AD patients. It has been reported that in animal models of AD, exposure to aluminum (Al) or copper (Cu) enhanced oxidative events and accumulation of amyloid beta (Abeta) peptides. The present study was designed to evaluate the effect of a 3-month exposure of mice to copper sulfate (8 microM), aluminum lactate (10 or 100 microM), or a combination of the salts. Results suggest that although Al or Cu may independently initiate inflammatory or oxidative events, they may function cooperatively to increase APP levels.Entities:
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Year: 2006 PMID： 16697052 DOI： 10.1016/j.jneuroim.2006.03.025
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478