G N Ioannou1, I W Liou, N S Weiss. 1. Northwest Hepatitis C Resource Center, Veternas Affairs Puget Sound Health Care System, Gastroenterology, Seattle, WA 98108, USA. georgei@medicine.washington.edu
Abstract
BACKGROUND: Bilirubin has antioxidant properties and has been postulated to protect against the development of malignancies. AIM: To investigate whether baseline serum bilirubin concentration predicts the incidence of colorectal cancer in a nationally representative sample of the US population. METHODS: Participants of the first National Health and Nutrition Examination Survey were divided into four groups based on quartiles of baseline serum bilirubin concentration in mg/dL: <0.38 (n = 1410), 0.38 to <0.5 (n = 1287), 0.5 to <0.6 (n = 1048) and > or = 0.6 (n = 1742). The incidence of colorectal cancer during the following 20 years was determined from hospitalization records and death certificates. RESULTS: 110 cases of colorectal cancer-related death or hospitalization were identified among 5487 participants during 88,339 person-years of follow-up (12 per 10,000 person-years). There was no association between baseline serum bilirubin concentration and the incidence of colorectal cancer either in unadjusted analyses or after adjusting for age, gender, ethnicity, smoking, body mass index, alcohol consumption and educational attainment. CONCLUSIONS: Baseline serum bilirubin concentration did not predict the subsequent incidence of colorectal cancer in this population-based cohort study.
BACKGROUND:Bilirubin has antioxidant properties and has been postulated to protect against the development of malignancies. AIM: To investigate whether baseline serum bilirubin concentration predicts the incidence of colorectal cancer in a nationally representative sample of the US population. METHODS:Participants of the first National Health and Nutrition Examination Survey were divided into four groups based on quartiles of baseline serum bilirubin concentration in mg/dL: <0.38 (n = 1410), 0.38 to <0.5 (n = 1287), 0.5 to <0.6 (n = 1048) and > or = 0.6 (n = 1742). The incidence of colorectal cancer during the following 20 years was determined from hospitalization records and death certificates. RESULTS: 110 cases of colorectal cancer-related death or hospitalization were identified among 5487 participants during 88,339 person-years of follow-up (12 per 10,000 person-years). There was no association between baseline serum bilirubin concentration and the incidence of colorectal cancer either in unadjusted analyses or after adjusting for age, gender, ethnicity, smoking, body mass index, alcohol consumption and educational attainment. CONCLUSIONS: Baseline serum bilirubin concentration did not predict the subsequent incidence of colorectal cancer in this population-based cohort study.
Authors: Eva Sticova; Milan Elleder; Helena Hulkova; Ondrej Luksan; Martin Sauer; Irena Wunschova-Moudra; Jan Novotny; Milan Jirsa Journal: World J Gastroenterol Date: 2013-02-14 Impact factor: 5.742
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Authors: Nazlisadat Seyed Khoei; Mazda Jenab; Neil Murphy; Barbara L Banbury; Robert Carreras-Torres; Vivian Viallon; Tilman Kühn; Bas Bueno-de-Mesquita; Krasimira Aleksandrova; Amanda J Cross; Elisabete Weiderpass; Magdalena Stepien; Andrew Bulmer; Anne Tjønneland; Marie-Christine Boutron-Ruault; Gianluca Severi; Franck Carbonnel; Verena Katzke; Heiner Boeing; Manuela M Bergmann; Antonia Trichopoulou; Anna Karakatsani; Georgia Martimianaki; Domenico Palli; Giovanna Tagliabue; Salvatore Panico; Rosario Tumino; Carlotta Sacerdote; Guri Skeie; Susana Merino; Catalina Bonet; Miguel Rodríguez-Barranco; Leire Gil; Maria-Dolores Chirlaque; Eva Ardanaz; Robin Myte; Johan Hultdin; Aurora Perez-Cornago; Dagfinn Aune; Konstantinos K Tsilidis; Demetrius Albanes; John A Baron; Sonja I Berndt; Stéphane Bézieau; Hermann Brenner; Peter T Campbell; Graham Casey; Andrew T Chan; Jenny Chang-Claude; Stephen J Chanock; Michelle Cotterchio; Steven Gallinger; Stephen B Gruber; Robert W Haile; Jochen Hampe; Michael Hoffmeister; John L Hopper; Li Hsu; Jeroen R Huyghe; Mark A Jenkins; Amit D Joshi; Ellen Kampman; Susanna C Larsson; Loic Le Marchand; Christopher I Li; Li Li; Annika Lindblom; Noralane M Lindor; Vicente Martín; Victor Moreno; Polly A Newcomb; Kenneth Offit; Shuji Ogino; Patrick S Parfrey; Paul D P Pharoah; Gad Rennert; Lori C Sakoda; Clemens Schafmayer; Stephanie L Schmit; Robert E Schoen; Martha L Slattery; Stephen N Thibodeau; Cornelia M Ulrich; Franzel J B van Duijnhoven; Korbinian Weigl; Stephanie J Weinstein; Emily White; Alicja Wolk; Michael O Woods; Anna H Wu; Xuehong Zhang; Pietro Ferrari; Gabriele Anton; Annette Peters; Ulrike Peters; Marc J Gunter; Karl-Heinz Wagner; Heinz Freisling Journal: BMC Med Date: 2020-09-03 Impact factor: 8.775