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Literature DB >> 16696003

Absence of Epstein-Barr virus in oesophageal squamous cell carcinoma.

K Y Lam¹, G Srivastava, M L Leung, L Ma.

Abstract

Aim-To identify the possible role of Epstein-Barr virus (EBV), in Chinese patients, in the pathogenesis of oesophageal squamous cell carcinoma.Methods-Formalin fixed, paraffin wax embedded tissues from 74 cases of oesophageal squamous cell carcinoma (28 with well differentiated, 27 with moderately differentiated and 18 with poorly differentiated carcinomas) were analysed for EBV using in situ hybridisation for EBV encoded small RNAs.Results-EBV was detected in only a few lymphocytes adjacent to the tumour epithelia in 14 (19%) cases of oesophageal carcinoma. The adjacent, non-pathological oesophageal tissue was EBV negative.Conclusions-EBV does not play a major role in the aetiology of oesophageal squamous cell carcinoma.

Entities: Chemical Disease Species

Year: 1995 PMID： 16696003 PMCID： PMC407959 DOI： 10.1136/mp.48.4.m188

Source DB: PubMed Journal: Clin Mol Pathol ISSN： 1355-2910

16 in total

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Journal: Int J Cancer Date: 1988-02-15 Impact factor: 7.396

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Authors: Q Tao; G Srivastava; S L Loke; R H Liang; Y T Liu; F C Ho
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Authors: M Mori; M Watanabe; S Tanaka; K Mimori; H Kuwano; K Sugimachi
Journal: Arch Pathol Lab Med Date: 1994-10 Impact factor: 5.534

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Authors: S J Hamilton-Dutoit; G Pallesen
Journal: Histopathology Date: 1994-08 Impact factor: 5.087