Literature DB >> 16691489

The occluded nucleotide conformation of p-glycoprotein.

Gregory Tombline1, Alan E Senior.   

Abstract

We review recent work on E552A/E1197A P-glycoprotein. This ATPase-defective mutant occludes MgATP tightly with maximal 1/1 stoichiometry in drug-sensitive fashion. The occluded nucleotide conformation appears to represent a transient, asymmetric, catalytic intermediate. We present a model for catalysis incorporating nucleotide binding domain (NBD) dimerization and the occluded nucleotide conformation, and we speculate as to how catalysis seen in P-glycoprotein might be harmonized with symmetrical dimer structures of isolated NBDs.

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Year:  2005        PMID： 16691489     DOI： 10.1007/s10863-005-9498-4

Source DB:  PubMed          Journal:  J Bioenerg Biomembr        ISSN： 0145-479X            Impact factor:   2.945


  29 in total

1.  Functional characterization and ATP-induced dimerization of the isolated ABC-domain of the haemolysin B transporter.

Authors:  Jelena Zaitseva; Stefan Jenewein; Alexander Wiedenmann; Houssain Benabdelhak; I Barry Holland; Lutz Schmitt
Journal:  Biochemistry       Date:  2005-07-19       Impact factor: 3.162

2.  Inhibition of P-glycoprotein ATPase activity by beryllium fluoride.

Authors:  B Sankaran; S Bhagat; A E Senior
Journal:  Biochemistry       Date:  1997-06-03       Impact factor: 3.162

3.  The E. coli BtuCD structure: a framework for ABC transporter architecture and mechanism.

Authors:  Kaspar P Locher; Allen T Lee; Douglas C Rees
Journal:  Science       Date:  2002-05-10       Impact factor: 47.728

4.  Involvement of the "occluded nucleotide conformation" of P-glycoprotein in the catalytic pathway.

Authors:  Gregory Tombline; Alma Muharemagić; Lori Bartholomew White; Alan E Senior
Journal:  Biochemistry       Date:  2005-09-27       Impact factor: 3.162

5.  Both P-glycoprotein nucleotide-binding sites are catalytically active.

Authors:  I L Urbatsch; B Sankaran; S Bhagat; A E Senior
Journal:  J Biol Chem       Date:  1995-11-10       Impact factor: 5.157

6.  Synergy between conserved ABC signature Ser residues in P-glycoprotein catalysis.

Authors:  Gregory Tombline; Lori Bartholomew; Khursheed Gimi; Grace A Tyndall; Alan E Senior
Journal:  J Biol Chem       Date:  2003-11-24       Impact factor: 5.157

7.  Stoichiometry and affinity of nucleotide binding to P-glycoprotein during the catalytic cycle.

Authors:  Qin Qu; Paula L Russell; Frances J Sharom
Journal:  Biochemistry       Date:  2003-02-04       Impact factor: 3.162

8.  Conformational transitions induced by the binding of MgATP to the vitamin B12 ATP-binding cassette (ABC) transporter BtuCD.

Authors:  Eliud O Oloo; D Peter Tieleman
Journal:  J Biol Chem       Date:  2004-08-11       Impact factor: 5.157

9.  Nucleotide dependent monomer/dimer equilibrium of OpuAA, the nucleotide-binding protein of the osmotically regulated ABC transporter OpuA from Bacillus subtilis.

Authors:  Carsten Horn; Erhard Bremer; Lutz Schmitt
Journal:  J Mol Biol       Date:  2003-11-28       Impact factor: 5.469

10.  ATP binding to the motor domain from an ABC transporter drives formation of a nucleotide sandwich dimer.

Authors:  Paul C Smith; Nathan Karpowich; Linda Millen; Jonathan E Moody; Jane Rosen; Philip J Thomas; John F Hunt
Journal:  Mol Cell       Date:  2002-07       Impact factor: 17.970
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  21 in total

1.  Direct Spectroscopic Detection of ATP Turnover Reveals Mechanistic Divergence of ABC Exporters.

Authors:  Alberto Collauto; Smriti Mishra; Aleksei Litvinov; Hassane S Mchaourab; Daniella Goldfarb
Journal:  Structure       Date:  2017-07-14       Impact factor: 5.006

2.  Both maltose-binding protein and ATP are required for nucleotide-binding domain closure in the intact maltose ABC transporter.

Authors:  Cedric Orelle; Tulin Ayvaz; R Michael Everly; Candice S Klug; Amy L Davidson
Journal:  Proc Natl Acad Sci U S A       Date:  2008-08-25       Impact factor: 11.205

3.  Strict coupling between CFTR's catalytic cycle and gating of its Cl- ion pore revealed by distributions of open channel burst durations.

Authors:  László Csanády; Paola Vergani; David C Gadsby
Journal:  Proc Natl Acad Sci U S A       Date:  2009-12-04       Impact factor: 11.205

4.  Reaction chemistry ABC-style.

Authors:  Alan E Senior
Journal:  Proc Natl Acad Sci U S A       Date:  2011-08-26       Impact factor: 11.205

Review 5.  Two ATPases.

Authors:  Alan E Senior
Journal:  J Biol Chem       Date:  2012-07-20       Impact factor: 5.157

6.  Dynamic ligand-induced conformational rearrangements in P-glycoprotein as probed by fluorescence resonance energy transfer spectroscopy.

Authors:  Brandy Verhalen; Stefan Ernst; Michael Börsch; Stephan Wilkens
Journal:  J Biol Chem       Date:  2011-11-15       Impact factor: 5.157

7.  Mechanism of allosteric modulation of P-glycoprotein by transport substrates and inhibitors.

Authors:  Reza Dastvan; Smriti Mishra; Yelena B Peskova; Robert K Nakamoto; Hassane S Mchaourab
Journal:  Science       Date:  2019-05-17       Impact factor: 47.728

8.  Stimulation of the maltose transporter ATPase by unliganded maltose binding protein.

Authors:  Alister D Gould; Patrick G Telmer; Brian H Shilton
Journal:  Biochemistry       Date:  2009-08-25       Impact factor: 3.162

9.  Characterization of an asymmetric occluded state of P-glycoprotein with two bound nucleotides: implications for catalysis.

Authors:  Alena Siarheyeva; Ronghua Liu; Frances J Sharom
Journal:  J Biol Chem       Date:  2010-01-08       Impact factor: 5.157

Review 10.  Genomics and the mechanism of P-glycoprotein (ABCB1).

Authors:  Zuben E Sauna; In-Wha Kim; Suresh V Ambudkar
Journal:  J Bioenerg Biomembr       Date:  2007-12       Impact factor: 2.945
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