| Literature DB >> 16690318 |
George N Ziakas1, Eleni A Rekka, Antonios M Gavalas, Phaedra T Eleftheriou, Panos N Kourounakis.
Abstract
Amine or amide derivatives bearing the 2,6-di-tert-butyl phenol moiety are synthesised. Almost all are antioxidants, reduce acute inflammation and inhibit COX-1 and lipoxygenase activity. The most potent anti-inflammatory, COX-1 inhibitor and antioxidant agent, with low toxicity, is 2,6-di-tert-butyl-4-thiomorpholin-4-ylmethyl-phenol.Entities:
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Year: 2006 PMID： 16690318 DOI： 10.1016/j.bmc.2006.04.030
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641