Literature DB >> 16687173

Analysis of complex chromosomal rearrangements in adult patients with MDS and AML by multicolor FISH.

Libuse Babicka1, Sarka Ransdorfova, Jana Brezinova, Zuzana Zemanova, Lenka Sindelarova, Magda Siskova, Jacqueline Maaloufova, Jaroslav Cermak, Kyra Michalova.   

Abstract

We analyzed complex chromosomal aberrations in 37 adult patients with myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) using classical cytogenetic method, FISH with locus-specific probes, multicolor FISH (mFISH) and multicolor banding (mBAND). Unbalanced structural aberrations, leading to a gain or loss of chromosomal material, were frequently observed in bone marrow cells. In 30 patients (81.1%) loss or rearrangement of chromosome 5, 7 and/or 11 was found. The most frequent numerical change was trisomy 8 as expected (detected in six patients-16.2%) and the most frequent breakpoints 5q13, 5q33, 7q31, 10p12, 11q23, 12p13, 17p11 and 21q22 were determined.

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Year:  2006        PMID： 16687173     DOI： 10.1016/j.leukres.2006.03.010

Source DB:  PubMed          Journal:  Leuk Res        ISSN： 0145-2126            Impact factor:   3.156


  5 in total

Review 1.  Cytogenetic, molecular genetic, and clinical characteristics of acute myeloid leukemia with a complex karyotype.

Authors:  Krzysztof Mrózek
Journal:  Semin Oncol       Date:  2008-08       Impact factor: 4.929

2.  Acute myelomonocytic leukemia with dysplastic bone marrow eosinophils showing t(5;17)(q13;q11) and a secondary chromosomal aberration, inv(16)(p13q22).

Authors:  Rika Sakai; Katsumichi Fujimaki; Etsuko Yamazaki; Hiroshi Sakamoto; Heiwa Kanamori; Ikuo Miura; Yoshiaki Ishigatsubo
Journal:  Int J Hematol       Date:  2006-12       Impact factor: 2.490

3.  Relationship of treatment-related cytopenias and response to lenalidomide in patients with lower-risk myelodysplastic syndromes.

Authors:  Mikkael A Sekeres; Jaroslaw P Maciejewski; Aristotle A N Giagounidis; Kenton Wride; Robert Knight; Azra Raza; Alan F List
Journal:  J Clin Oncol       Date:  2008-11-17       Impact factor: 44.544

4.  Proposed minimal diagnostic criteria for myelodysplastic syndromes (MDS) and potential pre-MDS conditions.

Authors:  Peter Valent; Attilio Orazi; David P Steensma; Benjamin L Ebert; Detlef Haase; Luca Malcovati; Arjan A van de Loosdrecht; Torsten Haferlach; Theresia M Westers; Denise A Wells; Aristoteles Giagounidis; Michael Loken; Alberto Orfao; Michael Lübbert; Arnold Ganser; Wolf-Karsten Hofmann; Kiyoyuki Ogata; Julie Schanz; Marie C Béné; Gregor Hoermann; Wolfgang R Sperr; Karl Sotlar; Peter Bettelheim; Reinhard Stauder; Michael Pfeilstöcker; Hans-Peter Horny; Ulrich Germing; Peter Greenberg; John M Bennett
Journal:  Oncotarget       Date:  2017-07-05

5.  A Novel Acquired t(2;4)(q36.1;q24) with a Concurrent Submicroscopic del(4)(q23q24) in An Adult with Polycythemia Vera.

Authors:  Eigil Kjeldsen
Journal:  Cancers (Basel)       Date:  2018-06-25       Impact factor: 6.639
  5 in total

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