Literature DB >> 16685656

Elevated expression and genetic association links the SOCS3 gene to atopic dermatitis.

E Ekelund1, A Saaf, M Tengvall-Linder, E Melen, J Link, J Barker, N J Reynolds, S J Meggitt, J Kere, C-F Wahlgren, G Pershagen, M Wickman, M Nordenskjold, I Kockum, M Bradley.   

Abstract

In a systematic analysis of global gene-expression patterns, we found that SOCS3 messenger RNA was significantly more highly expressed in skin from patients with atopic dermatitis than in skin from healthy controls, and immunohistochemical analysis confirmed a similar elevation of SOCS3 protein. Furthermore, we found a genetic association between atopic dermatitis and a haplotype in the SOCS3 gene in two independent groups of patients (P<.02 and P<.03). These results strongly suggest that SOCS3, located in a chromosomal region previously linked to the disease (17q25), is a susceptibility gene for atopic dermatitis.

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Year:  2006        PMID： 16685656      PMCID： PMC1474106          DOI： 10.1086/504272

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  20 in total

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