Literature DB >> 16680636

Deep sedation with propofol for upper gastrointestinal endoscopy in children, administered by specially trained pediatricians: a prospective case series with emphasis on side effects.

E Barbi1, P Petaros, L Badina, T Pahor, I Giuseppin, E Biasotto, S Martelossi, G Di Leo, A Sarti, A Ventura.   

Abstract

BACKGROUND AND STUDY AIMS: The need to administer procedural sedation to children has increased in recent years, as has experience in this field among nonanesthesiologists. Using propofol makes it easier to achieve sufficiently deep sedation. There is a considerable literature on the administration of propofol by nonanesthesiologists for gastroscopy in adults, but very few data are available on this issue in children. The aim of the present study was to assess the safety and efficacy of procedural sedation with propofol for gastroscopy in a pediatric ward with trained personnel and monitoring facilities. PATIENTS AND METHODS: A training protocol was developed to educate nurses and residents. Children requiring gastroscopy were included in the study prospectively and underwent procedural sedation with propofol administered by nonanesthesiologists.
RESULTS: A total of 811 upper gastrointestinal endoscopies were carried out with procedural sedation. Sedation was achieved in all procedures, and all but three (0.4%) were conducted successfully. None of the patients required intubation. Stridor with signs of upper airway obstruction occurred in 14 of the 811 procedures (1.7%). Laryngoscopy was required to manage difficulties in introducing the gastroscope in 16 of the 811 procedures (2.0%). Major desaturation requiring a short course of ventilation occurred in six procedures (0.7%), and transient desaturation that resolved spontaneously occurred in 97 of the procedures (12%).
CONCLUSIONS: Administration of propofol by nonanesthesiologists for gastroscopy examinations in children was successful in this study, but was associated with a small risk of potentially severe complications. Although the residents were generally able to administer procedural sedation alone, constant and immediate availability of anesthesiological support continues to be mandatory.

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Year:  2006        PMID: 16680636     DOI: 10.1055/s-2005-921194

Source DB:  PubMed          Journal:  Endoscopy        ISSN: 0013-726X            Impact factor:   10.093


  15 in total

Review 1.  Options and Considerations for Procedural Sedation in Pediatric Imaging.

Authors:  John W Berkenbosch
Journal:  Paediatr Drugs       Date:  2015-10       Impact factor: 3.022

2.  General considerations and updates in pediatric gastrointestinal diagnostic endoscopy.

Authors:  Yong Joo Kim
Journal:  Korean J Pediatr       Date:  2010-09-13

Review 3.  Analgesia and sedation for painful interventions in children and adolescents.

Authors:  Christoph Neuhäuser; Bendicht Wagner; Matthias Heckmann; Markus A Weigand; Klaus-Peter Zimmer
Journal:  Dtsch Arztebl Int       Date:  2010-04-09       Impact factor: 5.594

4.  The management of procedural pain at the Italian Centers of Pediatric Hematology-Oncology: state-of-the-art and future directions.

Authors:  Chiara Po'; Franca Benini; Laura Sainati; Maria Immacolata Farina; Simone Cesaro; Caterina Agosto
Journal:  Support Care Cancer       Date:  2011-12-31       Impact factor: 3.603

5.  Comparison of Ketamine and Propofol-Based Regimens for Deep Sedation in Children Undergoing Esophagogastroduodenoscopy.

Authors:  Olugbenga Akingbola; Sudesh K Srivastav; Michelle Nguyen; Dinesh Singh; Edwin M Frieberg; Amy Thibodeaux
Journal:  J Pediatr Intensive Care       Date:  2020-11-23

6.  Clinical effectiveness of an anesthesiologist-administered intravenous sedation outside of the main operating room for pediatric upper gastrointestinal endoscopy in Thailand.

Authors:  Somchai Amornyotin; Prapun Aanpreung
Journal:  Int J Pediatr       Date:  2010-08-02

7.  Propofol versus Midazolam for Sedation during Esophagogastroduodenoscopy in Children.

Authors:  Ji Eun Oh; Hae Jeong Lee; Young Hwan Lee
Journal:  Clin Endosc       Date:  2013-07-31

8.  Percutaneous closure of atrial septal defects in spontaneously breathing children under deep sedation: a feasible and safe concept.

Authors:  Andreas Hanslik; Axel Moysich; K Thorsten Laser; Elisabeth Mlczoch; Deniz Kececioglu; Nikolaus A Haas
Journal:  Pediatr Cardiol       Date:  2013-07-30       Impact factor: 1.655

9.  Procedural sedation analgesia.

Authors:  Saad A Sheta
Journal:  Saudi J Anaesth       Date:  2010-01

10.  Morbidity and mortality of endoscopist-directed nurse-administered propofol sedation (EDNAPS) in a tertiary referral center.

Authors:  Marie Ooi; Andrew Thomson
Journal:  Endosc Int Open       Date:  2015-08-11
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