Literature DB >> 16679604

A dimer of alpha- and beta-dihydroartemisinin: bis(3,6,9-trimethyl-3,12-epidioxy-3,4,5,5a,6,7,8,8a,9,10-decahydro-12H-pyrano[4,3-j][1,2]benzodioxepin-10-yl) ether.

Zheng Yu Yue1, Shu Hui Li, Po Gao, Jin Hui Zhang, Peng Fei Yan.   

Abstract

The title compound, C30H46O9, prepared from a mixture of alpha- and beta-dihydroartemisinin, has alpha- and beta-arteether moieties linked via an -O- bridge, so that the molecule is asymmetric about the bridge. The endoperoxide bridges of the parent compounds have been retained in each half of the ether-bridged dimer. The rings exhibit chair and twist-boat conformations.

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Year:  2006        PMID: 16679604     DOI: 10.1107/S0108270106009048

Source DB:  PubMed          Journal:  Acta Crystallogr C        ISSN: 0108-2701            Impact factor:   1.172


  4 in total

1.  Antimalarial activity and metabolism of dihydroartemisinin-derived dimer.

Authors:  Guoshun Zhang; Hualing Dai; Guolian Ren; Xiaoyang Xiao; Lele Zhao; Ruili Wang; Shuqiu Zhang
Journal:  Parasitol Res       Date:  2018-05-15       Impact factor: 2.289

2.  A second polymorph of β-arteether.

Authors:  Jerry P Jasinski; Ray J Butcher; H S Yathirajan; B Narayana; T V Sreevidya
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-02-13

3.  Redetermination of dihydro-artemisinin at 103 (2) K.

Authors:  Jerry P Jasinski; Ray J Butcher; H S Yathirajan; B Narayana; T V Sreevidya
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2007-12-06

4.  1,2-Bis[(3,6,9-trimethyl-3,12-ep-oxy-3,4,5,5a,6,7,8,8a,9,10,12,12a-dodeca-hydro-pyrano[4,3-j][1,2]benzodioxepin-4-yl)-oxy]ethane.

Authors:  Liwei Jia; Zhengyu Yue; Dongying Lv; Po Gao
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-02-10
  4 in total

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