| Literature DB >> 16677862 |
Nesty Olivares1, Annette León, Yamilé López, Alina Puig, Armando Cádiz, Gustavo Falero, Máximo Martínez, Marie E Sarmiento, Mildrey Fariñas, Juan F Infante, Gustavo Sierra, Rosa L Solís, Armando Acosta.
Abstract
The effect of the administration of a commercial preparation of human gamma globulins has been evaluated in a mouse model of intranasal infection with BCG. First, we demonstrated the passage of specific antibodies to saliva and lung lavage following the intranasal or intraperitoneal administration to mice of human gamma globulins. This treatment of mice inhibited BCG colonization of the lungs (p < 0.01). A similar inhibitory effect was observed after infection of mice with gamma globulin opsonized BCG organisms (p < 0.01). These results are relevant for the development of new strategies for the control and treatment of tuberculosis.Entities:
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Year: 2006 PMID： 16677862 DOI： 10.1016/j.tube.2006.01.006
Source DB: PubMed Journal: Tuberculosis (Edinb) ISSN： 1472-9792 Impact factor: 3.131