UNLABELLED: Oxidized low-density lipoproteins (ox-LDL) play a significant role in the development of atherosclerosis. OBJECTIVE: To investigate the relation between circulating ox-LDL and components of the metabolic syndrome (MS) in a sample of 124 postmenopausal women with varying glucose tolerance status. METHODS: This cross-sectional study included postmenopausal women not using hormone therapy. Ox-LDL concentrations were measured in plasma by a monoclonal antibody (mAb-4E6) based competition ELISA. LDL peak particle diameter (LDL-PPD) was measured by non-denaturating polyacrylamide gradient gel electrophoresis (PAGGE). Presence of the MS was determined according to the definition of the NCEP-ATPIII. RESULTS: Circulating ox-LDL concentrations were significantly associated with some factors of the MS such as triglyceride (r=0.48; p<0.0001), high-density lipoprotein cholesterol (r=-0.34; p=0.0001) and fasting plasma glucose concentrations (r=0.21; p=0.02). Ox-LDL concentrations were also associated with LDL cholesterol (r=0.54; p<0.0001), total cholesterol (r=0.48; p<0.0001), LDL apolipoprotein B (r=0.62; p<0.0001) and LDL-PPD (r=-0.18; p<0.05). Moreover, women with the MS had significantly higher ox-LDL concentrations (79.5+/-28.3 U/l) compared to women without the MS (64.2+/-19.9 U/l) (p<0.05). CONCLUSION: Ox-LDL concentrations are associated with individual components of the MS and are significantly higher in postmenopausal women with MS compared to healthy postmenopausal women.
UNLABELLED: Oxidized low-density lipoproteins (ox-LDL) play a significant role in the development of atherosclerosis. OBJECTIVE: To investigate the relation between circulating ox-LDL and components of the metabolic syndrome (MS) in a sample of 124 postmenopausal women with varying glucose tolerance status. METHODS: This cross-sectional study included postmenopausal women not using hormone therapy. Ox-LDL concentrations were measured in plasma by a monoclonal antibody (mAb-4E6) based competition ELISA. LDL peak particle diameter (LDL-PPD) was measured by non-denaturating polyacrylamide gradient gel electrophoresis (PAGGE). Presence of the MS was determined according to the definition of the NCEP-ATPIII. RESULTS: Circulating ox-LDL concentrations were significantly associated with some factors of the MS such as triglyceride (r=0.48; p<0.0001), high-density lipoprotein cholesterol (r=-0.34; p=0.0001) and fasting plasma glucose concentrations (r=0.21; p=0.02). Ox-LDL concentrations were also associated with LDL cholesterol (r=0.54; p<0.0001), total cholesterol (r=0.48; p<0.0001), LDL apolipoprotein B (r=0.62; p<0.0001) and LDL-PPD (r=-0.18; p<0.05). Moreover, women with the MS had significantly higher ox-LDL concentrations (79.5+/-28.3 U/l) compared to women without the MS (64.2+/-19.9 U/l) (p<0.05). CONCLUSION: Ox-LDL concentrations are associated with individual components of the MS and are significantly higher in postmenopausal women with MS compared to healthy postmenopausal women.
Authors: Joseph M Devaney; Paul D Thompson; Paul S Visich; William A Saltarelli; Paul M Gordon; E Funda Orkunoglu-Suer; Heather Gordish-Dressman; Brennan T Harmon; Margaret K Bradbury; Karuna Panchapakesan; Rahul Khianey; Monica J Hubal; Priscilla M Clarkson; Linda S Pescatello; Robert F Zoeller; Niall M Moyna; Theodore J Angelopoulos; William E Kraus; Eric P Hoffman Journal: Pediatr Res Date: 2011-06 Impact factor: 3.756
Authors: Anne L Norris; Julia Steinberger; Lyn M Steffen; Andrea M Metzig; Sarah Jane Schwarzenberg; Aaron S Kelly Journal: Obesity (Silver Spring) Date: 2011-02-17 Impact factor: 5.002
Authors: Aaron S Kelly; David R Jacobs; Alan R Sinaiko; Antoinette Moran; Lyn M Steffen; Julia Steinberger Journal: Pediatr Diabetes Date: 2010-12 Impact factor: 4.866
Authors: Kiriaque B F Barbosa; Ana Carolina P Volp; Helen Hermana M Hermsdorff; Iñigo Navarro-Blasco; M Ángeles Zulet; J Alfredo Martínez; Josefina Bressan Journal: Lipids Health Dis Date: 2011-04-19 Impact factor: 3.876