| Literature DB >> 16675784 |
Mohamed S Arredouani1, Zhiping Yang, Amy Imrich, Yaoyu Ning, Guozhong Qin, Lester Kobzik.
Abstract
The class A macrophage scavenger receptor SR-AI/II is implicated as a pattern recognition receptor for innate immunity, but its functional role in lung defense has not been studied. We used mice genetically deficient in SR-AI/II and their wild-type C57BL/6 counterparts to investigate the contribution of this receptor to defense against pneumococcal infection and inhaled particles. SR-AI/II deficiency caused impaired phagocytosis of fluorescent bacteria in vivo, diminished clearance of live bacteria from the lungs, and substantially increased pneumonic inflammation. Survival studies also showed increased mortality in SR-AI/II-deficient mice with pneumococcal lung infection. Similarly, after challenge of the airways with TiO(2) particles, SR-AI/II-deficient mice showed increased proinflammatory cytokine levels in lung lavage fluid and a more pronounced neutrophilic inflammation. The data indicate that the lung macrophage class A scavenger receptor SR-AI/II contributes to innate defense against bacteria and inhaled particles.Entities:
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Year: 2006 PMID： 16675784 PMCID： PMC2643266 DOI： 10.1165/rcmb.2006-0128OC
Source DB: PubMed Journal: Am J Respir Cell Mol Biol ISSN： 1044-1549 Impact factor: 6.914