| Literature DB >> 16675218 |
Pankaj G Roy1, Alastair M Thompson.
Abstract
Cyclin D1 is one of the frequently overexpressed proteins and one of the commonly amplified genes in breast cancer. This article reviews the roles of cyclin D1 in cell-cycle regulation (normal and abnormal), mammary gland development and carcinogenesis and the relationship to oestrogen in breast tissues. It concludes by presenting the clinical, prognostic and therapeutic implications of our current knowledge of cyclin D1 in breast cancer.Entities:
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Year: 2006 PMID： 16675218 DOI： 10.1016/j.breast.2006.02.005
Source DB: PubMed Journal: Breast ISSN： 0960-9776 Impact factor: 4.380